Thermo Scientific™

Opti-Link™ Carboxylate-Modified Particles

Control sensitivity, specificity and stability with various acid content available within Thermo Scientific™ Opti-Link™ Carboxylate-Modified Particles. Particles contain carboxylic acid groups for covalent coupling and can be used directly from the bottle in a variety of applications.
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  • Parking area combines surface area and acid content to give you the surface acid distribution that is useful for assay optimization
  • Surface area per gram of a particle varies inversely with the particle diameter
  • Acid content refers to the titrated milliequivalents per gram (mEq/g) and is weight-based
  • For most applications, particles can be used directly from the bottle without any pre-cleaning
  • Proprietary anionic surfactant does not interfere with binding of proteins nor cause proteins to desorb from particle surfaces or cause proteins to desorb from particle surfaces
  • Various surface acid concentrations available to help optimize reagent development efforts
  • Particles have been used in and are equally successful in molecular biology and research applications

Parking Area Properties

  • Low Acid Content—60–100 Parking Area—Hydrophobic surface, more colloidally stable than plain polystyrene
  • Medium Acid Content—35–59 Parking Area—Hydrophobic and hydrophilic areas; good colloidal stability and good covalent coupling
  • High Acid Content—10–34 Parking Area—Hydrophilic surface; excellent colloidal stability; excellent covalent coupling

Recommended for:

  • Clinical diagnostics
  • Molecular biology
  • Nephelometric, turbidimetric and slide agglutination assays


When using Opti-Link particles, ask about our Microparticle Reagent Optimization manual, which outlines our reagent development strategy. This manual includes validated binding, coupling and particle reagent optimization protocols.