UK Biobank Axiom™ Array was designed by and for thought leaders in the human genetics community for high-throughput, high-value genotyping of large sample cohorts to explore the genetics of complex diseases and translational research with a single comprehensive low-cost solution. This array contains one 96-array plate that allows for genome-wide genotyping of large sample collections such as those screened at biobanks, genome centers, and core labs.
GWAS • Intelligent marker selection enables imputation of millions of additional SNPs • The genomic content module of each array is optimized for specific populations and is customizable to any 1000 Genomes population study by adding additional markers of your choosing
Pharmacogenomic markers • Markers were selected to represent phases of absorption, distribution, metabolism, and excretion (ADME)
Inflammation and HLA • Contains markers with evidence for association with autoimmune and inflammation • Covers variants in genes in the HLA and KIR regions known to be important in immune response
Exome • Rare, non-synonymous coding SNPs and indels in protein coding regions of the genome • A majority of variants are rare with minor allele frequency (MAF) <1% • Newly discovered loss-of-function content • SNPs and indels identified from a sequencing initiative of 26,000 individuals • Known disease-causing mutations
eQTLs • Markers that have known associations to RNA expression traits • Captures unique eQTLs contained in the NCBI Genotype-Tissue Expression (GTEx) eQTL database, GEUVIDAS project, and several other discovery projects
Human disease • Alzheimer-s disease, including coverage of ApoE • Blood phenotypes • Cancer common variants • Cardiometabolic
Choose your content • Order the pre-designed array and customize it with markers of your choice • Custom markers may be de novo or selected from the Axiom Genomic Database of genotype-tested markers
Please note: Reagent kits do not include plastic consumables required to run the assay on the Beckman Biomek™ FXP Target Prep Express System. Please contact us for a list of required plastic consumables.
For Research Use Only. Not for use in diagnostic procedures.