PharmacoScan™ Assay Kit, 24-Format
Applied Biosystems™
PharmacoScan™ Assay Kit, 24-Format
Each PharmacoScan™ Assay Kit includes all necessary array plates, reagents, controls, and consumables to process 88 samples (and 8 controls)Read more
Have Questions?
Catalog number 903010TS
also known as 903010
Price (USD)/ 88 samples
-
Request A Quote

Each PharmacoScan™ Assay Kit includes all necessary array plates, reagents, controls, and consumables to process 88 samples (and 8 controls) with the PharmacoScan Solution workflow

PharmacoScan Solution is an ideal platform for translational researchers in healthcare, pharma, and research organizations looking to understand how genetic variations affect drug absorption, distribution, metabolism, and excretion (ADME).

By pre-emptively screening for risk factors on a microarray, users in research can precisely and reproducibly analyze 4,627 high- to low-evidence markers* within nearly 1,200 genes* in a single assay. The solution includes copy number variation calling and interrogating predictive markers in complex genes. Unlike solutions that analyze only high-evidence markers, PharmacoScan Solution presents a more comprehensive view for genotyping for pharmacogenomic risk.

Key Features:
• 4,627 markers in 1,191 genes of known pharmacogenomic value
• Comprehensive content of known pharmacogenomic value including Phase I and Phase II enzymes, regulatory/modifier genes, drug target genes, and Phase III/transporter genes
• Comprehensive content of known pharmacogenomic value including Phase I and Phase II enzymes, regulatory/modifier genes, drug target genes, and Phase III/transporter genes
• Genotyping of highly predictive markers in genes including GSTM1, CYP1A2, CYP2D6, CYP2B6, CYP2A6, SULT1A1, CYP2C19, and CYP2C9 that are in highly homologous regions
• Copy number variation (CNV) analysis for copy number states ranging from zero to three-plus for important ADME genes
• Star allele and translation for key genes

Contents:
• PharmacoScan Solution broadly screens for pharmacogenomic risk factors for research and leverages content carefully selected from top global consortia.
• Core functional pharmacogenomic content including markers from Clinical Pharmacogenomics Implementation Consortium (CPIC) guidelines
• Pharmacogenomics Knowledgebase (PharmGKB) markers in Very Important Pharmacogenes (VIP)
• PharmGKB markers with clinical annotations
• PharmaADME core markers
• Nearly all markers from DMET Plus Solution (1,936 genetic variants across 231 relevant genes)
• Human leukocyte antigen (HLA) markers associated with drug reactions
• Markers for killer cell immunoglobulin-like receptors (KIR), human ancestry identification, and for sample ID and tracking
• Pharmacogenetics/ADME markers in genes targeted for European populations drawn from UK Biobank Axiom Array

Continuity of content for cohort studies and clinical trials
Drug development research and clinical trials are typically conducted over several years. These long-term efforts require a platform that can guarantee multiyear availability of 100% of the specific array content for the entire timeline of initiative. Unlike bead-based technologies that experience batch-to-batch variability and single nucleotide polymorphism (SNP) dropouts with each manufacturing batch, the photolithography manufacturing technology used in PharmacoScan array guarantees 100% fidelity and ensures all markers are present on every manufacturing batch for as long as necessary, addressing a major concern for such long-term efforts.

PharmacoScan Solution utilizes the same chemistry from the Axiom™ assay and GeneTitan™ Multi-Channel (MC) Instrument, a microarray platform preferred worldwide by genetic researchers for the efficient workflow, high throughput, and reproducibility of results critical to multiyear data collection and analysis efforts.

Compatible with Axiom Analysis Suite software, version 5.1.1.

*Disclaimer: Number of variants genotyped by default as well as variant to gene mapping is refined over time.

For Research Use Only. Not for use in diagnostic procedures.
Specifications
TypeAssay Kit
ArrayGenotyping
Number of Arrays4 arrays
Format24-array Plate
SpeciesHuman
For Use With (Application)Microarray Analysis
No. of Samples88 samples
Quantity88 samples
Unit Size88 samples
Contents & Storage
4 x 24-format array plates. Store at 2-8°C

1 x Reagent Kit (Includes reagents and controls for 4x24-format array plates). Storage can vary for each reagent. Refer to product insert.

Gene Titan instrument consumables for 4x24-format array plates. Store at room temp.