BacMam LRRK2 D1994A Reagent is a modified insect cell virus (baculovirus) that enables easy, efficient, and titratable overexpression of full-length D1994A LRRK2 (kinase-dead LRRK2 mutant) in your choice of cellular background, including primary neurons and neuroblastoma cell lines. BacMam LRRK2 D1994A Reagent Lets You:
• Investigate LRRK2 mutation mechanisms and stimulus responses
• Assay LRRK2 relevance across a broad range of parameters
• Utilize most mammalian cellular backgrounds for LRRK2 overexpression Examine LRRK2 Mutations with BacMam Reagents
Use of the BacMam LRRK2 therapeutic mutant reagents G2019S (Cat. no. A13389
) and D1994A in addition to the wild-type LRRK2 reagent (Cat. no. A13388
) enables you to research and determine LRRK2 mutant mechanisms. You can also evaluate the differences in cellular response to a stimulus among the different mutations. Expand Your Battery of Cellular Assays for LRRK2
Once full length LRRK2 D1994A has been introduced into your cellular background, the transduced cells allow you the flexibility to conduct many types of LRRK2 research. Some examples include studying the regulation of physiologically functional pathways (including signaling pathways leading to function), or identification of potential physiological substrates for LRRK2. Overexpress Full-Length LRRK2 in Most Mammalian Cell Backgrounds
BacMam technology utilizes a modified baculovirus to deliver and express genes in mammalian cells with minimal effort and toxicity. It enables efficient, titratable LRRK2 D1994A protein expression in various mammalian cellular backgrounds, including cell lines that may not be compatible with traditional transfection methods such as primary neurons and neuroblastoma cell lines.
For research use only. Not intended for any human or animal therapeutic or diagnostic use.Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen® Eu Kinase Binding Assay
• LanthaScreen® Activity Assay
• Learn More About BacMam Technology
For Research Use Only. Not for use in diagnostic procedures.