This kit contains a rabbit Tb-anti-GST antibody—an equivalent kit containing a goat-sourced antibody is also available.

LanthaScreen® TR-FRET RAR gamma Coactivator Assay Kit, rabbit

Catalog number: A15123

 Related applications: Pharma & Biopharma | Target & Lead Identification & Validation

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This kit contains Rabbit Tb-Anti-GST antibody; other kit components are the same as kit PV4411:

The LanthaScreen® TR-FRET Retinoic Acid Receptor (RAR) gamma Coactivator Assay Kit provides a sensitive and robust method for high-throughput screening of potential RAR gamma ligands as agonists of coactivator recruitment. The homogeneous mix-and-read assay format results in a ligand EC50 composite value representing the amount of ligand required to bind to receptor, effect a conformational change, and recruit coactivator peptide (Figure 1).

How it works

The LanthaScreen® TR-FRET RAR gamma Coactivator Assay Kit includes a terbium (Tb)-labeled anti-GST antibody, a fluorescein-labeled coactivator peptide, and a human RAR gamma ligand-binding domain (RAR gamma-LBD) that is tagged with glutathione-S-transferase (GST). To assay, RAR gamma-LBD is added to ligand test compounds, followed by addition of a mixture of the fluorescein-coactivator peptide and Tb-anti-GST antibody. After room temperature incubation, the TR-FRET 520:495 emission ratio is calculated and used to determine the EC50 from a dose response curve of the compound.

Contents and Storage:

The LanthaScreen® TR-FRET RAR gamma Coactivator Assay Kit contains RAR gamma-LBD (GST) protein, fluorescein-labeled PGC1a coactivator peptide, Tb-anti-GST antibody, and buffers. Store components as indicated in the assay protocol (-80°C, -20°C, or +4°C).
For Research Use Only. Not for use in diagnostic procedures.


Color: Green
Format: 384-well plate
Readout: TR-FRET (Activity)
Technique: TR-FRET
Label or Dye: Tb (Terbium)
Product Size: 800 x 20 µL assays
Detection Method: Fluorescent
Druggable Target: Nuclear Receptors
Validated Application: Nuclear Receptor Assay
For Use With (Equipment): Microplate Reader

Contents & storage

Tb-anti-GST Antibody (Rabbit): Store at -20 °C
RAR gamma-LBD, GST: Store at -80 °C
Fluoroscein Coactivator Peptide: Store at -20 °C
TR-FRET Coregulatore Buffer C: Store at 4 °C
1M DTT: Store at -20 °C or -80 °C


Manuals & protocols