N,N-Dimethylformamide dimethyl acetal, 94%
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N,N-Dimethylformamide dimethyl acetal, 94%
N,N-Dimethylformamide dimethyl acetal, 94%
N,N-Dimethylformamide dimethyl acetal, 94%
Thermo Scientific Chemicals

N,N-Dimethylformamide dimethyl acetal, 94%

CAS: 4637-24-5 | C5H13NO2 | 119.16 g/mol
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Catalog number A15350.36
also known as A15350-36
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Chemical Identifiers
CAS4637-24-5
IUPAC Name(dimethoxymethyl)dimethylamine
Molecular FormulaC5H13NO2
InChI KeyZSXGLVDWWRXATF-UHFFFAOYSA-N
SMILESCOC(OC)N(C)C
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)Clear colorless
FormLiquid
Assay (GC)≥92.0%
Identification (FTIR)Conforms
Refractive Index1.3940-1.3990 @ 20°C
N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Solubility
Miscible with most organic solvents.

Notes
Moisture sensitive. Incompatible with strong oxidizing agents and acids.
RUO – Research Use Only

General References:

  1. Lee, H. J.; Lee, S.; Yu, J.; Kim, J. N. Vinylogous N,N-dimethylaminomethylenation of 3-[(1-substituted) ethylidene]-oxindoles with N,N-dimethylformamide dimethylacetal. Tetrahedron Lett. 2014, 55 (15), 2450-2454.
  2. Prek, B.; Grošelj, U.; Kasunič, M.; Zupančič, S.; Svete, J.; Stanovnik, B. Reactions of Methyl Ketones and (Hetero)arylcarboxamides with N, N-Dimethylacetamide Dimethyl Acetal. A Simple Metal-Free Synthesis of 2, 4, 6-Trisubstituted Pyridines. Aust. J. Chem. 2015, 68 (2), 184-195.