LanthaScreen™ TR-FRET Glucocorticoid Receptor Competitive Binding Kit

      LanthaScreen™ TR-FRET Glucocorticoid Receptor Competitive Binding Kit

      Catalog number: A15901

       Related applications: Pharma & Biopharma | Target & Lead Identification & Validation

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      Description

      The LanthaScreen® TR-FRET Glucocorticoid Receptor Competitive Binding Assay Kit provides a sensitive and robust method for high-throughput screening (HTS) of ligands for glucocorticoid receptor (GR). The kit uses a human GR ligand-binding domain (GR-LBD) tagged with glutathione S-transferase (GST) (also available separately), a terbium-labeled anti-GST antibody, and a fluorescent small-molecule GR ligand (Fluormone™ GS1) in a homogeneous mix-and-read assay format.

      The Lanthascreen Gluococorticoid Receptor Competitive Binding Assay is:

      • Complete & ready-to-use out of the box—all reagents included, just add your test compounds
      • High throughput compatible—TR-FRET assays in a 384-well plate
      • Convenient—components available in bulk sizes for larger screening needs
      For Research Use Only. Not for use in diagnostic procedures.

      Specifications

      Product Line: LanthaScreen®
      Product Size: 800 x 20 µL assays
      Validated Application: Competitive Binding Assay, Nuclear Receptor Assay

      Contents & storage

      1 tube GR Ligand Binding Domain Recombinant Protein (store at -68 to -85°C)
      1 tube of Fluormone GS1 (store at -5 to -30°C)
      2 bottles Buffer (store at -5 to -30°C)
      1 tube Tb-Anti-GST Ab (store at -5 to -30°C)
      5 tubes GR Stabilizing Peptide (store at -5 to -30°C)
      1 tube of DTT (store at -5 to -30°C)

      Documents

      Manuals & protocols