Thermo Scientific Chemicals

Ácido indol-5-carboxílico, 98 %, Thermo Scientific Chemicals

Número de catálogo: A18627.14
25 g, Each
Thermo Scientific Chemicals

Ácido indol-5-carboxílico, 98 %, Thermo Scientific Chemicals

Número de catálogo: A18627.14
25 g, Each
Cantidad
Número de catálogo: A18627.14
también denominado A18627-14
Precio (EUR)
Cantidad
-

Identificadores químicos

CAS
1670-81-1
IUPAC Name
1H-indole-5-carboxylate
Molecular Formula
C9H6NO2
InChI Key
IENZCGNHSIMFJE-UHFFFAOYSA-M
SMILES
[O-]C(=O)C1=CC=C2NC=CC2=C1
Assay (HPLC)
≥97.5%
Appearance (Color)
White to cream to yellow
Assay (Aqueous acid-base Titration)
≥97.5 to ≤102.5%
Form
Powder
Melting Point (clear melt)
208.0-214.0?C

Descripción

Indole-5-carboxylic acid is the suitable reagent used to study the intermolecular excited state proton transfer in indole-2-carboxylic acid and indole-5-carboxylic acid in various solvents in acidic, basic, and neutral media by steady state and time resolved fluorescence spectroscopy. It may be used in the electrochemical synthesis of poly(indole-5-carboxylic acid) (PICA) films. Also used as reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, as potential anticancer immunomodulators, synthesis of indirubin derivatives and amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
El ácido indol-5-carboxílico es el reactivo adecuado utilizado para estudiar la transferencia de protones de estado de excitación intermolecular en el ácido indol-2-carboxílico y ácido indol-5-carboxílico en varios disolventes en medios ácidos, básicos y neutros mediante espectroscopía de fluorescencia de estado estable y con resolución temporal. Puede usarse en la síntesis electroquímica de películas de ácido poli(indol-5-carboxílico) (PICA). También se utiliza como reactante para la preparación de piridil-etenil-indoles de inhibidores de triptófano dioxigenasa, como potenciales inmunomoduladores anticancerosos, en la síntesis de derivados de la indirubina y conjugados de amida con ketoprofeno, como inhibidores de la transcripción mediada por Gli1 en la vía Hedgehog.

Solubilidad
Soluble en etanol (50 mg/ml), dimetilsulfóxido y metanol.

Notas
Almacenar en un lugar fresco. Mantenga el recipiente bien cerrado en un lugar seco y bien ventilado. Almacénese lejos de los agentes oxidantes.
RUO – Research Use Only

Figuras

Documentos y descargas

Certificados

    Preguntas frecuentes

    Citas y referencias

    Search citations by name, author, journal title or abstract text

    Seguridad y manipulación


    Classification of the substance or mixture
    CLP classification - Regulation(EC) No 1272/2008
    Acute oral toxicity
    Category 4
    Acute dermal toxicity
    Category 4
    Skin Corrosion/Irritation
    Category 2
    Serious Eye Damage/Eye Irritation
    Category 2
    Specific target organ toxicity - (single exposure)
    Category 3
    Label Elements
    Signal Word

    Warning

    Hazard Statements

    H302 + H312 - Harmful if swallowed or in contact with skin

    H315 - Causes skin irritation

    H319 - Causes serious eye irritation

    H335 - May cause respiratory irritation

    Precautionary Statements

    P261 - Avoid breathing dust/fume/gas/mist/vapors/spray

    P280 - Wear protective gloves/protective clothing/eye protection/face protection

    P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell

    P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

    P280 - Wear protective gloves/protective clothing/eye protection/face protection

    P302 + P352 - IF ON SKIN: Wash with plenty of soap and water