2,2,2-Tribromoetanol, 99 %, Thermo Scientific Chemicals

Name: 2,2,2-Tribromoetanol, 99 %, Thermo Scientific Chemicals
SKU: A18706.22

CAS: 75-80-9 | C2H3Br3O | 282.757 g/mol

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5 g

25 g

100 g

Número de catálogo A18706.22

también denominado A18706-22

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Cantidad:

100 g

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Identificadores químicos

CAS75-80-9

IUPAC Name2,2,2-tribromoethan-1-ol

Molecular FormulaC2H3Br3O

InChI KeyYFDSDPIBEUFTMI-UHFFFAOYSA-N

SMILESOCC(Br)(Br)Br

Especificaciones Specification Sheet

Hoja de especificaciones

Water Content (Karl Fischer Titration)<1.0%

FormCrystalline powder or crystals or powder and/or lumps

Appearance (Color)White to cream to pale brown

Assay (GC)≥98.5%

2,2,2-Tribromoethanol is utilized in organic synthesis of beta-amino alcohols. The pharmaceutical preparation of tribromoethanol serves as an anesthetic in medicine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
El 2,2,2-tribromoetanol se utiliza en la síntesis orgánica de alcoholes beta-aminoácidos. La preparación farmacéutica del tribromoetanol sirve como anestésico en medicina.

Solubilidad
soluble en alcohol, éter, benceno y éter de petróleo caliente. Parcialmente soluble en agua.

Notas
Sensible a la luz. Almacenar en un lugar fresco y bien ventilado. Mantener el recipiente herméticamente cerrado.

RUO – Research Use Only

General References:

Carboxyl groups can be protected as tribromoethyl esters, e.g. by reaction of the acid chloride in the presence of N,N-dimethylaniline. The group is readily cleaved with Zn/AcOH: J. Chem. Soc., Pekin 1., 2875 (1993); (cf. 2,2,2-Trichloroethanol, L08163). The group has also been exploited in the activation of carboxylic acids for amidation with amines, by reductive cleavage of the tribromoethyl ester with a P(III) reagent, preferably Hexamethyl phosphorous triamide, A12571, and triethylamine. In an analogous esterification method with alcohols, tributylphosphine - DMAP was the preferred system: J. Org. Chem., 64, 1430 (1999).
Maheras, K. J.; Gow, A. Increased anesthesia time using 2,2,2-tribromoethanol-chloral hydrate with low impact on mouse psychoacoustics. J. Neurosci. Methods 2013, 219 (1), 61-69.
Jong, W. M. C.; Zuurbier, C. J.; Winter, R. J.; Van den Heuvel, D. A. F.; Reitsma, P. H.; Cate, H. T.; Ince, C. Fentanyl-fluanisone-midazolam Combination Results in More Stable Hemodynamics than does Urethane-α-chloralose and 2,2,2-tribromoethanol in Mice. J. Am. Assoc. Lab. Anim. Sci. 2002, 41 (3), 28-32.