LiquidBiopsy™ Instrument

Catalog number: A28188

Ion Torrent™  Related applications: Digital PCR | Ion Torrent™ Next-Generation Sequencing

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The Ion Torrent™ LiquidBiopsy™ Instrument automates isolation of circulating tumor cells (CTCs) from whole-blood samples. Achieving high target cell recovery and exceptional purity, the instrument enables downstream molecular characterization of rare cells using next-generation sequencing.

The LiquidBiopsy Instrument is part of the LiquidBiopsy™ Platform for rare cell isolation in research.

The LiquidBiopsy Platform:
• Is part of a comprehensive, cost effective, sample-to-variant workflow
• Is uniquely suited to low-input DNA sequencing without the need for whole genome amplification
• Enables highly multiplexed analyses
• Achieves a limit of detection down to <1%, critical for CTC research
• Provides rapid turnaround time, completing the sample-to-variant workflow in 2 days

Walkaway automation
The LiquidBiopsy Instrument automates flow cell priming, blood sample loading, target cell isolation, and immunofluorescence labeling of captured cells on a flow chip with the same form factor as a standard pathology slide.

Comprehensive workflow
The comprehensive, two-day LiquidBiopsy Platform sequencing workflow enables the generation of genomic research reporting data on CTCs, cell-free DNA (cfDNA), and germline whole blood cells from a single blood sample in a single cycle. Captured cells are pooled on a single Ion 318™ Chip and sequenced on the Ion PGM™ Sequencer. Resulting data may be analyzed using Ion Reporter™ Software.

High capture rate
The LiquidBiopsy Instrument uses proprietary flow chip technology that eliminates the need for whole genome amplification, a process that typically introduces false positives in the data.

The flow chip makes possible a highly pure capture for CTCs that facilitates downstream NGS analysis. The high capture rate is the result of an EpCAM-based immunocapture methodology that also allows for a cocktail of antibodies to be used for a more diverse cell recovery.

Highly sensitive multiplexing
Coupled with Ion Torrent sequencing technology, the LiquidBiopsy Platform achieves up to 100% sensitivity down to <1% allele frequency at 2,000x read depth. Using the power of Ion AmpliSeq™ technology, the platform allows for multiplexing as many as four samples, and yields more data from low-input DNA commonly obtained from CTCs. The Ion PGM Sequencer is a scalable, cost-effective sequencing solution that allows analysis of incremental numbers of samples that effectively support research applications without the need to batch samples.
For Research Use Only. Not for use in diagnostic procedures.


Product Size: 1 unit
Shipping Condition: Room Temperature
For Use With (Equipment): Ion PGM™ System


Manuals & protocols