Hypoxia-inducible factor-2α (HIF-2α) is a transcription factor responsible for regulating genes related to angiogenesis and metabolism. This study aims to explore the effect of a previously unreported mutation c.C2473T (p.R825S) in the C-terminal transactivation domain (CTAD) of HIF-2α that we detected in tissue of patients with liver disease. We sequenced ... More
Profiling of oxBS-450K 5-hydroxymethylcytosine in human placenta and brain reveals enrichment at imprinted loci.
AuthorsHernandez Mora JR,Sanchez-Delgado M,Petazzi P,Moran S,Esteller M,Iglesias-Platas I,Monk D
JournalEpigenetics
PubMed ID28678681
DNA methylation (5-methylcytosine, 5âmC) is involved in many cellular processes and is an epigenetic mechanism primarily associated with transcriptional repression. The recent discovery that 5âmC can be oxidized to 5-hydromethylcytosine (5hmC) by TET proteins has revealed the âsixth baseâ of DNA and provides additional complexity to what was originally thought ... More
Molecular Evolution and Epidemiological Characteristics of SARS COV-2 in (Northwestern) Poland.
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) evolved into a worldwide outbreak, with the first Polish cases in February/March 2020. This study aimed to investigate the molecular epidemiology of the circulating virus lineages between March 2020 and February 2021. We performed variant identification, spike mutation pattern analysis, and ... More
Bacteria and protozoa with pathogenic potential in Ixodes ricinus ticks in Viennese recreational areas.
AuthorsSchötta AM,Stelzer T,Stanek G,Stockinger H,Wijnveld M
JournalWiener klinische Wochenschrift
PubMed ID35689113
Ixodes ricinus is the most relevant vector for tick-borne diseases in Austria and responsible for the transmission of Borrelia burgdorferi sensu lato (s.â¯l.), which causes Lyme borreliosis in humans; however, also other bacteria and protozoa can be found in ticks and have the potential of infecting people and animals. In ... More
β-Catenin/Lin28/let-7 regulatory network determines type II alveolar epithelial stem cell differentiation phenotypes following thoracic irradiation.
The contribution of type II alveolar epithelial stem cells (AEC II) to radiation-induced lung fibrosis (RILF) is largely unknown. Cell differentiation phenotypes are determined by the balance between Lin28 and lethal-7 microRNA (let-7 miRNA). Lin28 is activated by β-catenin. The aim of this study was to track AEC II phenotypes ... More
CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.
Recent advances in the diagnosis of COVID-19: a bird's eye view.
AuthorsSharma B,Shahanshah MFH,Gupta S,Gupta V
JournalExpert review of molecular diagnostics
PubMed ID33423567
INTRODUCTION: The COVID-19 pandemic is still escalating and has shaped an extraordinary and pressing need for rapid diagnostics with high sensitivity and specificity. Prompt diagnosis is the key to mitigate this situation. As several diagnostic tools for COVID-19 are already available and others are still under development, mandating a comprehensive ... More
Uncovering the Effect and Mechanism of Rhizoma Corydalis on Myocardial Infarction Through an Integrated Network Pharmacology Approach and Experimental Verification.
AuthorsLi J,Wu J,Huang J,Cheng Y,Wang D,Liu Z
JournalFrontiers in pharmacology
PubMed ID35935870
Background: Myocardial infarction (MI), characterized by reduced blood flow to the heart, is a coronary artery disorder with the highest morbidity and mortality among cardiovascular diseases. Consequently, there is an urgent need to identify effective drugs to treat MI. Rhizoma Corydalis (RC) is the dry tuber of Corydalis yanhusuo W.T. ... More
Therapeutic Potential of AntagomiR-23b for Treating Myotonic Dystrophy.
AuthorsCerro-Herreros E,González-Martínez I,Moreno-Cervera N,Overby S,Pérez-Alonso M,Llamusí B,Artero R
JournalMolecular therapy. Nucleic acids
PubMed ID32805487
Myotonic dystrophy type 1 (DM1) is a chronically debilitating, rare genetic disease that originates from an expansion of a noncoding CTG repeat in the dystrophia myotonica protein kinase (DMPK) gene. The expansion becomes pathogenic when DMPK transcripts contain 50 or more repetitions due to the sequestration of the muscleblind-like (MBNL) ... More
Integrin-dependent migratory switches regulate the translocation of Toxoplasma-infected dendritic cells across brain endothelial monolayers.
AuthorsRoss EC,Ten Hoeve AL,Barragan A
JournalCellular and molecular life sciences : CMLS
PubMed ID34023934
Multiple cellular processes, such as immune responses and cancer cell metastasis, crucially depend on interconvertible migration modes. However, knowledge is scarce on how infectious agents impact the processes of cell adhesion and migration at restrictive biological barriers. In extracellular matrix, dendritic cells (DCs) infected by the obligate intracellular protozoan Toxoplasma ... More
A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation.
BACKGROUND: The anti-inflammatory effect of an α7nAChR agonist, PNU-282987, has previously been explored in the context of inflammatory disease. However, the effects of PNU-282987 on type 2 innate lymphoid cells (ILC2s)-mediated allergic airway inflammation has not yet been established. AIMS: To determine the effects of PNU-282987 on the function of ... More
Genital HSV-1 DNA detection is associated with a low inflammatory profile in HIV-uninfected South African women.
OBJECTIVES: Genital herpes simplex virus (HSV) infections are common in South Africa and worldwide. While HSV-2 is known to cause genital lesions, HSV-1 is better known to cause oral infections. Due to the global rise in genital HSV-1 infections, we aimed to compare the genital cytokine environment associated with HSV-1 ... More
Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour.
AuthorsJeong SH,Yang MJ,Choi S,Kim J,Koh GY
JournalNature communications
PubMed ID34285232
Stimulator of interferon genes (STING) promotes anti-tumour immunity by linking innate and adaptive immunity, but it remains unclear how intratumoural treatment with STING agonists yields anti-tumour effects. Here we demonstrate that intratumoural injection of the STING agonist cGAMP induces strong, rapid, and selective apoptosis of tumour endothelial cells (ECs) in ... More
Proteomic analysis reveals the molecular mechanism underlying the cold acclimation and freezing tolerance of wheat (Triticum aestivum L.).
In cereals, the vernalization-related gene network plays an important role in regulating the transition from the vegetative to the reproductive phase to ensure optimal reproduction in a temperate climate. In hexaploid bread wheat (Triticum aestivum L.), the spring growth habit is associated with the presence of at least one dominant ... More
PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-κB signaling in bladder cancer.
In vitro toxicological assessment of flumethrin's effects on MCF-7 breast cancer cells.
AuthorsKara-Ertekin S,Yazar S,Erkan M
JournalHuman & experimental toxicology
PubMed ID34142587
Curcumin and its analog alleviate diabetes-induced damages by regulating inflammation and oxidative stress in brain of diabetic rats.
AuthorsMiao C,Chen H,Li Y,Guo Y,Xu F,Chen Q,Zhang Y,Hu M,Chen G
JournalDiabetology & metabolic syndrome
PubMed ID33602334
BACKGROUND: Diabetic encephalopathy is a severe diabetes complication with cognitive dysfunction and neuropsychiatric disability. The mechanisms underlying diabetic encephalopathy is believed to be relevant with oxidative stress, vascular amylin deposition, immune receptors, inflammation, etc. This study wanted to evaluate the ability of curcumin and its analog A13 to alleviate oxidative ... More
HSP47 contributes to angiogenesis by induction of CCL2 in bladder cancer.
AuthorsMa W,Ou T,Cui X,Wu K,Li H,Li Y,Peng G,Xia W,Wu S
JournalCellular signalling
PubMed ID34000383
Modelling liver cancer microenvironment using a novel 3D culture system.
AuthorsAl Hrout A,Cervantes-Gracia K,Chahwan R,Amin A
JournalScientific reports
PubMed ID35568708
The tumor microenvironment and its contribution to tumorigenesis has been a focal highlight in recent years. A two-way communication between the tumor and the surrounding microenvironment sustains and contributes to the growth and metastasis of tumors. Progression and metastasis of hepatocellular carcinoma (HCC) have been reported to be exceedingly influenced by ... More
Gingival crevicular fluid infiltrating CD14+ monocytes promote inflammation in periodontitis.
AuthorsFageeh HN,Fageeh HI,Khan SS,Maganur PC,Vyas N,Patil VR,Raj AT,Baeshen HA,Patil S
JournalSaudi journal of biological sciences
PubMed ID34012332
Periodontitis is a condition that occurs because of inflammation-mediated tissue degeneration. Many studies have been conducted to identify inflammatory molecules in periodontitis, but the well-defined role of cells from the immune system in the progression of periodontitis as well as in gingival tissue degeneration has not been appropriately established. The ... More
Selection on the regulation of sympathetic nervous activity in humans and chimpanzees.
Adrenergic α(2)C receptor (ADRA2C) is an inhibitory modulator of the sympathetic nervous system. Knockout mice for this gene show physiological and behavioural alterations that are associated with the fight-or-flight response. There is evidence of positive selection on the regulation of this gene during chicken domestication. Here, we find that the ... More
Iturin A Rescued STb-R-Induced Pork Skeletal Muscle Growth Restriction through the Hypothalamic-Pituitary-mTORC1 Growth Axis.
AuthorsYe M,Liu Z,Gao C,Yan H,Wang X,Wen L,Jin C
JournalAnimals : an open access journal from MDPI
PubMed ID35739903
SIMPLE SUMMARY: Since antimicrobial peptides (AMPs) possess broad-spectrum antimicrobial activity and low drug resistance, their development as antibiotic alternatives are of interest. Previous studies reported that the performance of pigs was improved by AMPs through the protection of the intestine. Nevertheless, direct evidence linking AMPs and skeletal muscle growth is ... More
Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury.
Mesenchymal stem cells (MSCs) have attracted interest for their potential to alleviate liver injury. Here, the protective effect of MSCs on carbon tetrachloride (CCl(4))-induced acute liver injury (ALI) was investigated. In this study, we illustrated a novel mechanism that ferroptosis, a newly recognized form of regulated cell death, contributed to ... More
Early Growth Response 1 Suppresses Macrophage Phagocytosis by Inhibiting NRF2 Activation Through Upregulation of Autophagy During Pseudomonas aeruginosa Infection.
AuthorsPang Z,Xu Y,Zhu Q
JournalFrontiers in cellular and infection microbiology
PubMed ID35096638
Pseudomonas aeruginosa is an opportunistic pathogen that causes life-threatening infections in cystic fibrosis patients and immunocompromised individuals. A tightly regulated immune response possessed by healthy individuals can effectively control P. aeruginosa infections, whereas the patients with dysregulated immune response are susceptible to this bacterial pathogen. Early growth response 1 (Egr-1) ... More
SARS-CoV-2 airborne transmission: A validated sampling and analytical method.
AuthorsRobotto A,Civra A,Quaglino P,Polato D,Brizio E,Lembo D
JournalEnvironmental research
PubMed ID34324848
The airborne transmission path for SARS-CoV-2 is of primary scientific and health-related interest as it could actually involve management, accessibility, use and functionality of many activities, including hospitals), schools, workplaces, factories, transport, sport venues and outdoor environment. It is necessary to develop a sampling and analytical method for virus-laden bioaerosol ... More
Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infection.
Current coronavirus disease-19 (COVID-19) vaccines are administered by the intramuscular route, but this vaccine administration failed to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection in the upper respiratory tract, mainly due to the absence of virus-specific mucosal immune responses. It is hypothesized that intranasal (IN) vaccination could ... More
Reverse Genetics System for Heartland Bandavirus: NSs Protein Contributes to Heartland Bandavirus Virulence.
Heartland bandavirus (HRTV), which is an emerging tick-borne virus first identified in Missouri in 2009, causes fever, fatigue, decreased appetite, headache, nausea, diarrhea, and muscle or joint pain in humans. HRTV is genetically close to Dabie bandavirus, which is the causative agent of severe fever with thrombocytopenia syndrome (SFTS) in ... More
Transcriptome analysis of pituitary gland revealed candidate genes and gene networks regulating the growth and development in goose.
AuthorsTang J,Shen X,Ouyang H,Luo W,Huang Y,Tian Y,Zhang X
JournalAnimal biotechnology
PubMed ID32779547
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis.
Metastasis is the most common cause of death in cancer patients. Canonical drugs target mainly the proliferative capacity of cancer cells, which leaves slow-proliferating, persistent cancer cells unaffected. Metabolic determinants that contribute to growth-independent functions are still poorly understood. Here we show that antifolate treatment results in an uncoupled and ... More
Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection.
AuthorsRayner JO,Kim JH,Roberts RW,Wood RR,Fouty B,Solodushko V
JournalVaccines
PubMed ID33918409
Chikungunya virus (CHIKV) infection can result in chronic and debilitating arthralgia affecting humans in tropical and subtropical regions around the world, yet there are no licensed vaccines to prevent infection. DNA launched virus like particle (VLP) vaccines represent a potentially safer alternative to traditional live-attenuated vaccines; however, fully characterized immunocompetent ... More
Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant.
In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K444, L452, N460, and F486. Here, we characterize the convergent evolution of Omicron subvariants and the properties of one recent lineage of concern, ... More
Cloning and Functional Identification of Phosphoethanolamine Methyltransferase in Soybean (Glycine max).
AuthorsJi X,Wu X,Chen W,Yuan Q,Shen Y,Chi Y
JournalFrontiers in plant science
PubMed ID34386021
Phosphoethanolamine methyltransferase (PEAMT), a kind of S-adenosylmethionine-dependent methyltransferases, plays an essential role in many biological processes of plants, such as cell metabolism, stress response, and signal transduction. It is the key rate-limiting enzyme that catalyzes the three-step methylation of ethanolamine-phosphate (P-EA) to phosphocholine (P-Cho). To understand the unique function of ... More
Identification of SARS-CoV-2 Omicron variant using spike gene target failure and genotyping assays, Gauteng, South Africa, 2021.
AuthorsSubramoney K,Mtileni N,Bharuthram A,Davis A,Kalenga B,Rikhotso M,Maphahlele M,Giandhari J,Naidoo Y,Pillay S,Ramphal U,Ramphal Y,Tegally H,Wilkinson E,Mohale T,Ismail A,Mashishi B,Mbenenge N,de Oliveira T,Makatini Z,Fielding BC,Treurnicht FK,Network for Genomics Surveillance in South Africa
JournalJournal of medical virology
PubMed ID35441368
The circulation of Omicron BA.1 led to the rapid increase in severe acute respiratory syndrome coronavirus 2Â (SARSâCoVâ2) cases in South Africa in November 2021, which warranted the use of more rapid detection methods. We, therefore, assessed the ability to detect Omicron BA.1 using genotyping assays to identify specific mutations in ... More
Growth Performance, Survival, Blood Chemistry, and Immune Gene Expression of Channel Catfish (Ictalurus punctatus) Fed Probiotic-Supplemented Diets.
AuthorsNguyen KQ,Bruce TJ,Afe OE,Liles MR,Beck BH,Davis DA
JournalVeterinary sciences
PubMed ID36548862
SIMPLE SUMMARY: Two trials were performed, utilizing channel catfish fed probiotic-supplemented diets in flow-through systems under natural rearing conditions. There were no significant improvement in growth performance, survival, hematocrit, and blood chemistry parameters in channel catfish fed Bacillus velezensis-amended and Bacillus subtilis-amended diets. In the first trial, immune gene expression ... More
BHLHE41 Overexpression Alleviates the Malignant Behavior of Colon Cancer Cells Induced by Hypoxia via Modulating HIF-1α/EMT Pathway.
AuthorsChen S,Dong QJ,Wan ZA,Gao S,Tu SL,Chai R
JournalGastroenterology research and practice
PubMed ID35615737
OBJECTIVE: BHLHE41 has been shown to be a marker of tumorigenesis. Colon cancer (CC) is a common malignant tumor of colonic mucosa. This study mainly explored the mechanism of BHLHE41 in alleviating malignant behavior of hypoxia-induced CC cells. METHODS: The levels of BHLHE41 in CC and normal cell lines were ... More
Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice.
Autophagy is a catabolic process that degrades cytoplasmic constituents and organelles in the lysosome, thus serving an important role in cellular homeostasis and protection against insults. We previously reported that defects in autophagy contribute to neuronal cell damage in traumatic spinal cord injury (SCI). Recent data from other inflammatory models ... More
Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma.
Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2.
Pasteurella multocida primarily causes hemorrhagic septicemia and pneumonia in poultry and livestock. Identification of the relevant virulence factors is therefore essential for understanding its pathogenicity. Pmorf0222, encoding the PM0222 protein, is located on a specific prophage island of the pathogenic strain C48-1 of P. multocida. Its role in the pathogenesis ... More
LL-37 Exacerbates Local Inflammation in Sepsis-Induced Acute Lung Injury by Preventing Mitochondrial DNA (mtDNA) Degradation-Induced Autophagy.
AuthorsZuo Y,Dang R,Peng H,Wu Z,Yang Y
JournalMedical science monitor : international medical journal of experimental and clinical research
PubMed ID31422413
BACKGROUND: Recent studies have proved that autophagy dysfunction in proinflammatory cells is involved in tissue damage and an excessive inflammatory response in sepsis. In the present study, we identified that the human antimicrobial peptide LL-37 facilitates resistance to DNase II-induced mitochondrial DNA (mtDNA) degradation and subsequent autophagy. MATERIAL/METHODS: We found ... More
Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases.
BACKGROUND: Tissue organoids generated from human pluripotent stem cells are valuable tools for disease modelling and to understand developmental processes. While recent progress in human cardiac organoids revealed the ability of these stem cell-derived organoids to self-organize and intrinsically formed chamber-like structure containing a central cavity, it remained unclear the ... More
LPS-TLR4/MD-2-TNF-α signaling mediates alcohol-induced liver fibrosis in rats.
AuthorsMou WL,Chen SR,Wu ZT,Hu LH,Zhang JY,Chang HJ,Zhou H,Liu Y
JournalJournal of toxicologic pathology
PubMed ID35516842
Liver fibrosis results from liver inflammation and progresses to liver cirrhosis or liver cancer. It is known that nonalcoholic liver disease is mediated by the Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2)âtumor necrosis factor-alpha (TNF-α) signaling pathway. This study aimed to investigate whether alcoholic liver disease is also mediated by ... More
Comparative Analysis of Tomato Brown Rugose Fruit Virus Isolates Shows Limited Genetic Diversity.
Tomato is an important vegetable in the United States and around the world. Recently, tomato brown rugose fruit virus (ToBRFV), an emerging tobamovirus, has impacted tomato crops worldwide and can result in fruit loss. ToBRFV causes severe symptoms, such as mosaic, puckering, and necrotic lesions on leaves; other symptoms include ... More
IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis.
JournalJournal of experimental & clinical cancer research : CR
PubMed ID36522683
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most common digestive malignancies with relatively high morbidity and mortality. Emerging evidence suggests circular RNAs (circRNAs) play critical roles in tumor cell malignancy. However, the biological function and clinical significance of many circRNAs in ESCC remain elusive. METHODS: The expression level ... More
A critical role for hepatic protein arginine methyltransferase 1 isoform 2 in glycemic control.
JournalFASEB journal : official publication of the Federation of American Societies for Experimental Biology
PubMed ID32918517
Appropriate control of hepatic gluconeogenesis is essential for the organismal survival upon prolonged fasting and maintaining systemic homeostasis under metabolic stress. Here we show protein arginine methyltransferase 1 (PRMT1), a key enzyme that catalyzes the protein arginine methylation process, particularly the isoform encoded by Prmt1 variant 2 (PRMT1V2), is critical ... More
Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury.
AuthorsSánchez-Navarro A,Martínez-Rojas MÁ,Albarrán-Godinez A,Pérez-Villalva R,Auwerx J,de la Cruz A,Noriega LG,Rosetti F,Bobadilla NA
JournalInternational journal of molecular sciences
PubMed ID35269715
Acute kidney injury (AKI) is a public health problem worldwide. Sirtuins are a family of seven NAD+-dependent deacylases, Overexpression of Sirtuin 1, 3, and 5 protect against AKI. However, the role of Sirtuin 7 (Sirt7) in AKI is not known. Here, we analyzed how Sirt7 deficient mice (KO-Sirt7) were affected ... More
Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19) that has caused a pandemic with millions of human infections. There continues to be a pressing need to develop potential therapies and vaccines to inhibit SARS-CoV-2 infection to mitigate the ongoing pandemic. Epidemiological data ... More
Cigarette smoke-induced RANKL expression enhances MMP-9 production by alveolar macrophages.
AuthorsZhou L,Le Y,Tian J,Yang X,Jin R,Gai X,Sun Y
JournalInternational journal of chronic obstructive pulmonary disease
PubMed ID30587964
BACKGROUND AND PURPOSE: Cigarette smoke (CS) induces alveolar destruction through overproduction of proteinases including matrix metalloproteinase (MMP)-9 by alveolar macrophages (AMs). Receptor activator of nuclear factor-κB ligand (RANKL) functions in immune regulation and cytokine secretion; whether it is involved in CS-induced MMP-9 expression is unknown. The purpose of our study ... More
Long Noncoding RNA LINC02470 Sponges MicroRNA-143-3p and Enhances SMAD3-Mediated Epithelial-to-Mesenchymal Transition to Promote the Aggressive Properties of Bladder Cancer.
SIMPLE SUMMARY: Long noncoding RNAs (lncRNAs) were proposed as novel tumor prognostic markers, including for predicting bladder cancer progression, and the competing endogenous RNA (ceRNA) hypothesis conceived an accessible entry point to discover potential lncRNA candidates. This study indicated that LINC02470 promotes bladder cancer cell viability, migration, invasion, and in ... More
Enhanced myogenesis through lncFAM-mediated recruitment of HNRNPL to the MYBPC2 promoter.
The mammalian transcriptome comprises a vast family of long noncoding (lnc)RNAs implicated in physiologic processes such as myogenesis, through which muscle forms during embryonic development and regenerates in the adult. However, the specific molecular mechanisms by which lncRNAs regulate human myogenesis are poorly understood. Here, we identified a novel muscle-specific ... More
Superoxide Dismutase-3 Downregulates Laminin α5 Expression in Tumor Endothelial Cells via the Inhibition of Nuclear Factor Kappa B Signaling.
AuthorsCarmona-Rodríguez L,Martínez-Rey D,Martín-González P,Franch M,Sorokin L,Mira E,Mañes S
JournalCancers
PubMed ID35267534
SIMPLE SUMMARY: Tumor-infiltrating lymphocytes determine cancer prognosis and the response to immunotherapy. The balance of laminin-α4/laminin-α5 isoforms in the endothelial basement membrane plays an instructive function in regulating the diapedesis of immune cells under inflammatory conditions. Previous studies showed that the extracellular superoxide dismutase (SOD)3 induces laminin-α4, which is associated ... More
m6A-related long noncoding RNAs predict prognosis and indicate therapeutic response in endometrial carcinoma.
AuthorsZhou X,Zhang H,Duan Y,Zhu J,Dai H
JournalJournal of clinical laboratory analysis
PubMed ID36525280
BACKGROUND: N6âmethyladenosine (m6A) has been identified as the most common, abundant, and conserved internal transcriptional modification. Long noncoding RNAs (lncRNAs) are noncoding RNAs consisting of more than 200 nucleotides, and the expression of various lncRNAs may affect cancer prognosis. The impact of m6Aâassociated lncRNAs on uterine corpus endometrial carcinoma (UCEC) ... More
Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domain.
Neutralizing antibodies (NAbs) are believed to be promising prophylactic and therapeutic treatment against the coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we reported two mouse monoclonal antibodies 7Â Eb-4G and 1Baâ3H that specifically recognized the receptor-binding domain (RBD) of SARS-CoV-2 spike (S) ... More
Leptin Receptor Deficiency Results in Hyperphagia and Increased Fatty Acid Mobilization during Fasting in Rainbow Trout (Oncorhynchus mykiss).
Leptin is a pleiotropic hormone known for regulating appetite and metabolism. To characterize the role of leptin signaling in rainbow trout, we used CRISPR/Cas9 genome editing to disrupt the leptin receptor (LepR) genes, lepra1 and lepra2. We compared wildtype (WT) and mutant fish that were either fed to satiation or ... More
Research Note: Effects of dietary L-arginine on the production performance and gene expression of reproductive hormones in laying hens fed low crude protein diets.
AuthorsUyanga VA,Xin Q,Sun M,Zhao J,Wang X,Jiao H,Onagbesan OM,Lin H
JournalPoultry science
PubMed ID35339936
The present study was designed to investigate whether L-arginine (Arg) supplementation would influence the production performance and reproductive traits of laying hens fed low crude protein (LCP) diets. Hy-Line brown laying hens were randomly assigned to dietary treatments of control, LCP, and LCP supplemented with 0.05, 0.10, 0.15, or 0.20% ... More
VirPool: model-based estimation of SARS-CoV-2 variant proportions in wastewater samples.
AuthorsGafurov A,Baláž A,Amman F,Boršová K,Čabanová V,Klempa B,Bergthaler A,Vinař T,Brejová B
JournalBMC bioinformatics
PubMed ID36536300
BACKGROUND: The genomes of SARS-CoV-2 are classified into variants, some of which are monitored as variants of concern (e.g. the Delta variant B.1.617.2 or Omicron variant B.1.1.529). Proportions of these variants circulating in a human population are typically estimated by large-scale sequencing of individual patient samples. Sequencing a mixture of SARS-CoV-2 ... More
Novel cytokine-antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma.
AuthorsChu Y,Nayyar G,Kham Su N,Rosenblum JM,Soon-Shiong P,Lee J,Safrit JT,Barth M,Lee D,Cairo MS
JournalJournal for immunotherapy of cancer
PubMed ID33109629
BACKGROUND: The prognosis of patients with relapsed or progressive B cell (CD20( )) non-Hodgkinâs lymphoma (B-NHL), including Burkitt lymphoma (BL), is dismal due to chemoradiotherapy resistance. Novel therapeutic strategies are urgently needed. N-820 is a fusion protein of N-803 (formerly known as ALT-803) to four single-chains of rituximab. This agent ... More
Expression and activity of IL-17 receptor subunits in human cutaneous cells as targets for anti-IL-17 therapeutic antibodies.
Hundreds of genes have been associated with autism spectrum disorder (ASD), including loss-of-function mutations in chromodomain helicase DNA binding protein 8 (Chd8). Environmental factors also are implicated in autism risk and have the potential to exacerbate phenotypes in genetically sensitized backgrounds. Here we investigate transcriptional and behavioral phenotypes in a ... More
JNK/AP1 Pathway Regulates MYC Expression and BCR Signaling through Ig Enhancers in Burkitt Lymphoma Cells.
AuthorsDing X,Wang X,Zhu X,Zhang J,Zhu Y,Shao X,Zhou X
JournalJournal of Cancer
PubMed ID31942184
In Burkitt lymphoma (BL), a chromosomal translocation by which the MYC gene is fused to an immunoglobulin (Ig) gene locus is frequently found. The translocated MYC gene is overexpressed, which is the major driver of BL tumorigenesis. Studies have shown that Ig enhancers are essential for MYC overexpression, but the ... More
Metabolic contributions to neuronal deficits caused by genomic disruption of schizophrenia risk gene SETD1A.
AuthorsChong ZS,Khong ZJ,Tay SH,Ng SY
JournalSchizophrenia (Heidelberg, Germany)
PubMed ID36581615
Regulation of neuronal metabolism during early brain development is crucial for directing synaptic plasticity and proper circuit formation. Alterations in neuronal glycolysis or mitochondrial function are associated with several neuropsychiatric disorders, including schizophrenia. Recently, loss-of-function mutations in SETD1A, a histone methyltransferase, have been linked to increased schizophrenia risk and global ... More
Hapten sensitization to vaginal mucosa induces less recruitment of dendritic cells accompanying TGF-β-expressing CD206(+) cells compared with skin.
AuthorsNakayama K,Nishijo T,Miyazawa M,Watabe T,Azuma M,Sakaguchi H
JournalImmunity, inflammation and disease
PubMed ID35349751
INTRODUCTION: Contact hypersensitivity (CHS), a type of delayedâtype hypersensitivity, is induced by hapten exposure to the skin and mucosa. We previously reported that, in a murine model of CHS, the vaginal mucosa (VM) sensitization showed lower Tâcell responses as compared with the abdominal skin sensitization. To investigate mechanisms of impaired ... More
Synergistic Activity of Imipenem in Combination with Ceftazidime/Avibactam or Avibactam against Non-MBL-Producing Extensively Drug-Resistant Pseudomonas aeruginosa.
Extensively drug-resistant Pseudomonas aeruginosa (XDRPA) infection is a significant public health threat due to a lack of effective therapeutic options. New β-lactam-β-lactamase inhibitor combinations, including ceftazidime-avibactam (CZA), have shown a high resistance rate to XDRPA. This study was therefore conducted to describe the underlying genomic mechanism of resistance for CZA ... More
Deficiency of IKKα in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury.
AuthorsZhang F,Fan L,Zhang H,Huang WJ,Sun D,Pan BB,Wan X,Cao CC
JournalJournal of immunology research
PubMed ID34917688
Aims. Acute kidney injury (AKI) can lead to chronic kidney disease (CKD), and macrophages play a key role in this process. The aim of this study was to discover the role of IκB kinase α (IKKα) in macrophages in the process of AKI-to-CKD transition. Main Methods. We crossed lyz2-Cre mice ... More
A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics.
Frontotemporal dementia (FTD) is a heterogeneous clinical disorder characterized by progressive abnormalities in behavior, executive functions, personality, language and/or motricity. A neuropathological subtype of FTD, frontotemporal lobar degeneration (FTLD)-FET, is characterized by protein aggregates consisting of the RNA-binding protein fused in sarcoma (FUS). The cause of FTLD-FET is not well ... More
Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.
Whereas cysteine dioxygenase 1 (CDO1) expression is lost due to its hypermethylated promoter across a range of cancer types including gastric cancer (GC), its functions and molecular underpinnings remain largely unknown. Here we demonstrate that reduced CDO1 expression is indicative of unfavorable prognosis in patients with GC. CDO1 overexpression in ... More
Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles.
AuthorsJain R,Wade G,Ong I,Chaurasia B,Simcox J
JournalJournal of lipid research
PubMed ID35300982
Plasma lipid levels are altered in chronic conditions such as type 2 diabetes and cardiovascular disease as well as during acute stresses such as fasting and cold exposure. Advances in MS-based lipidomics have uncovered a complex plasma lipidome of more than 500 lipids that serve functional roles, including as energy ... More
Comparison of Trehalose/Hyaluronic Acid (HA) vs. 0.001% Hydrocortisone/HA Eyedrops on Signs and Inflammatory Markers in a Desiccating Model of Dry Eye Disease (DED).
AuthorsAstolfi G,Lorenzini L,Gobbo F,Sarli G,Versura P
JournalJournal of clinical medicine
PubMed ID35329844
Background: Dry eye disease (DED) is a multifactorial disease where ocular surface inflammation and damage play key etiological roles. Purpose: To compare a combination of 3% trehalose (T) and 0.15% hyaluronic acid (HA) (Thealoz duo(®), T/HA) with a tear substitute containing 0.001% hydrocortisone (I) and 0.2% HA (Idroflog(®), I/HA), with ... More
Seed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513.
MicroRNAs (miRNAs) are small post-transcriptional regulators that offer promising targets for treating complex diseases. To this end, hsa-miR-4513 is an excellent candidate as this gene harbors within its conserved heptametrical seed sequence a frequent polymorphism (rs2168518), which has previously been associated with several complex phenotypes. So far, little is known ... More
Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling.
Cold-induced activation of brown adipose tissue (BAT) has an important impact on systemic lipoprotein metabolism by accelerating the processing of circulating triglyceride-rich lipoproteins (TRL). Lipoprotein lipase (LPL) expressed by adipocytes is translocated via endothelial to the capillary lumen, where LPL acts as the central enzyme for the vascular lipoprotein processing. ... More
A leafhopper saliva protein mediates horizontal transmission of viral pathogens from insect vectors into rice phloem.
AuthorsWu W,Yi G,Lv X,Mao Q,Wei T
JournalCommunications biology
PubMed ID35246603
Numerous insects transmit viruses together with saliva to plant phloem, but the roles of saliva components remain elusive. Here, we report that calcium-binding protein (CBP), a universal insect saliva protein, is modified to benefit horizontal transmission of a devastating rice reovirus into plant phloem. CBP effectively competes with virus-induced filaments ... More
Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells.
Anastellin, a recombinant protein fragment from the first type III module of fibronectin, mimics a partially unfolded intermediate implicated in the assembly of fibronectin fibrils. Anastellin influences the structure of fibronectin and initiates in vitro fibrillation, yielding âsuperfibronectinâ, a polymer with enhanced cell-adhesive properties. This ability is absent in an ... More
An intranasal recombinant NDV-BRSV F(opt) vaccine is safe and reduces lesion severity in a colostrum-deprived calf model of RSV infection.
AuthorsSacco RE,Mena I,Palmer MV,Durbin RK,García-Sastre A,Durbin JE
JournalScientific reports
PubMed ID36581658
Human respiratory syncytial virus (HRSV) is a major cause of severe lower respiratory tract disease in infants and the elderly, yet no safe, effective vaccine is commercially available. Closely related bovine RSV (BRSV) causes respiratory disease in young calves, with many similar features to those seen in HRSV. We previously ... More
Validation of the Thermo Scientific SureTect™ Escherichia coli O157:H7 and STEC Screening PCR Assay and SureTect™ Escherichia coli STEC Identification PCR Assay for the Detection of Escherichia coli O157:H7 and the Escherichia coli STEC Serotypes (O26, O45, O103, O111, O121, O145) from Fresh Raw Spinach, Fresh Baby Leaves, Fresh Cut Tomatoes, Frozen Raw Beef, Raw Beef Trim, and Beef Carcass Sponges: AOAC Performance Tested MethodSM 012102.
BACKGROUND: The Thermo Scientific SureTect(â¢) Escherichia coli O157:H7 and STEC Screening PCR Assay and SureTect Escherichia coli STEC Identification PCR Assay are real-time PCR kits for the rapid detection of E. coli O157:H7 and non-E. coli O157 Shiga toxin-producing E. coli (STEC) serotypes (O26, O45, O103, O111, O121, O145) from ... More
TF-343 Alleviates Diesel Exhaust Particulate-Induced Lung Inflammation via Modulation of Nuclear Factor-κB Signaling.
AuthorsKim DI,Song MK,Kim SH,Park CY,Lee K
JournalJournal of immunology research
PubMed ID31781683
Inhalation of diesel exhaust particulate (DEP) causes oxidative stress-induced lung inflammation. This study investigated the protective effects of TF-343, an antioxidant and anti-inflammatory agent, in mouse and cellular models of DEP-induced lung inflammation as well as the underlying molecular mechanisms. Mice were intratracheally instilled with DEP or vehicle (0.05% Tween ... More
NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis.
Genetic mutations in nitrogen permease regulator-like 2 (NPRL2) are associated with a wide spectrum of familial focal epilepsies, autism, and sudden unexpected death of epileptics (SUDEP), but the mechanisms by which NPRL2 contributes to these effects are not well known. NPRL2 is a requisite subunit of the GAP activity toward ... More
Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon: In Vivo and Tissue Culture Studies.
Precocious male maturation causes reduced welfare and increased production costs in Atlantic salmon (Salmo salar) aquaculture. The pituitary produces and releases follicle-stimulating hormone (Fsh), the gonadotropin triggering puberty in male salmonids. However, little is known about how Fsh production is regulated in Atlantic salmon. We examined, in vivo and ex ... More
A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations.
Aging is a process of progressive change. To develop biological models of aging, longitudinal datasets with high temporal resolution are needed. Here we report a multi-omics longitudinal dataset for cultured primary human fibroblasts measured across their replicative lifespans. Fibroblasts were sourced from both healthy donors (nâ=â6) and individuals with lifespan-shortening ... More
The expression of essential selenoproteins during development requires SECIS-binding protein 2-like.
AuthorsKiledjian NT,Shah R,Vetick MB,Copeland PR
JournalLife science alliance
PubMed ID35210313
The dietary requirement for selenium is based on its incorporation into selenoproteins, which contain the amino acid selenocysteine (Sec). The Sec insertion sequence (SECIS) is an RNA structure found in the 3â² UTR of all selenoprotein mRNAs, and it is required to convert in-frame UGA codons from termination to Sec-incorporating ... More
Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice.
JournalNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
PubMed ID34610136
BACKGROUND: Osteocrin (OSTN), a bone-derived humoral factor, was reported to act on heart and bone by potentiating the natriuretic peptide (NP) system. Ostn gene polymorphisms have been associated with renal function decline, but its pathophysiological role in the kidney remains unclear. METHODS: The role of endogenous OSTN was investigated using ... More
Mutations and Phylogenetic Analyses of SARS-CoV-2 Among Imported COVID-19 From Abroad in Nanjing, China.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a pandemic and is threatening human health globally. The rapid genome sequencing and bioinformatic analysis of SARS-CoV-2 have become a helpful tool in the battle against the COVID-19. Here, we report the genetic characteristics, variations ... More
Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats.
Mutations in the putative glutamatergic synapse scaffolding protein SAP97 are associated with the development of schizophrenia in humans. However, the role of SAP97 in synaptic regulation is unclear. Here we show that SAP97 is expressed in the dendrites of granule neurons in the dentate gyrus but not in the dendrites ... More
circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis.
AuthorsZhang Z,Xia F,Yao L,Jiang B,Li X
JournalFrontiers in cell and developmental biology
PubMed ID35372340
Introduction: Thyroid cancer is the most common endocrine malignancy with Papillary Thyroid Carcinoma (PTC) as the most common pathological type. Due to low mortality but a high incidence, PTC still causes a relatively heavy burden on financial costs, human health, and quality of life. Emerging researches have indicated that circular ... More
An injectable self-adaptive polymer as a drug carrier for the treatment of nontraumatic early-stage osteonecrosis of the femoral head.
Core decompression (CD) with the elimination of osteonecrotic bone is the most common strategy for treating early-stage nontraumatic osteonecrosis of the femoral head (ONFH). Adjuvant treatments are widely used in combination with CD as suitable methods of therapy. Existing augmentations have to be fabricated in advance. Here, we report a ... More
Detection of deletion/insertion polymorphism profiles from single human hair shafts.
AuthorsTie J,Uchigasaki S,Isobe E,Iwakami E,Okuda T
JournalMolecular biology reports
PubMed ID34739693
Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut.
Atlantic Halibut (Hippoglossus hippoglossus) has a X/Y genetic sex determination system, but the sex determining factor is not known. We produced a high-quality genome assembly from a male and identified parts of chromosome 13 as the Y chromosome due to sequence divergence between sexes and segregation of sex genotypes in ... More
Innate immune training and metabolic reprogramming in primary monocytes of broiler and laying hens.
AuthorsVerwoolde MB,van den Biggelaar RHGA,de Vries Reilingh G,Arts JAJ,van Baal J,Lammers A,Jansen CA
JournalDevelopmental and comparative immunology
PubMed ID32750399
Monitored Implementation of COVID-19 Rapid Antigen Screening at Taxi Ranks in Johannesburg, South Africa.
Digital tools can support community-based decentralized testing initiatives to broaden access to COVID-19 diagnosis, especially in high-transmission settings. This operational study investigated the use of antigen-detecting rapid diagnostic tests (Ag-RDTs) for COVID-19 combined with an end-to-end digital health solution, in three taxi ranks in Johannesburg, South Africa. Members of the ... More
Clinical and Immunological Predictors of Hemorrhagic Fever with Renal Syndrome Outcome during the Early Phase.
The ability to accurately predict the early progression of hemorrhagic fever with renal syndrome (HFRS) is crucial for reducing morbidity and mortality rates in severely affected patients. However, the utility of biomarkers for predicting clinical outcomes remains elusive in HFRS. The aims of the current study were to analyze the ... More
MK2 Inhibitors as a Potential Crohn's Disease Treatment Approach for Regulating MMP Expression, Cleavage of Checkpoint Molecules and T Cell Activity.
AuthorsLebish EJ,Morgan NJ,Valentine JF,Beswick EJ
JournalPharmaceuticals (Basel, Switzerland)
PubMed ID36558958
Crohnâs Disease (CD) and Ulcerative Colitis (UC) are the two major forms of inflammatory bowel disease (IBD), which are incurable chronic immune-mediated diseases of the gastrointestinal tract. Both diseases present with chronic inflammation that leads to epithelial barrier dysfunction accompanied by loss of immune tolerance and inflammatory damage to the ... More
Small extravesicular microRNA in head and neck squamous cell carcinoma and its potential as a liquid biopsy for early detection.
BACKGROUND: The objective was to assess secretion of small extracellular vesicular microRNA (exoâmiRNA) in head and neck squamous cell carcinoma (HNSCC) according to human papillomavirus (HPV) status, and determine the translational potential as a liquid biopsy for early detection. METHODS: This study employed a combination of cell culture and caseâcontrol ... More
Characterization and functional analysis of GSK3β from Epinephelus coioides in Singapore grouper iridovirus infection.
Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance.
AuthorsChen Y,Li Y,Jia P,Ji S,Zhang H,Wang T
JournalAntioxidants (Basel, Switzerland)
PubMed ID35453351
The present study investigated the potential of polydatin to protect against liver injury and the mitochondrial dysfunction of weanling piglets suffering from intra-uterine growth retardation (IUGR). Thirty-six normal birth weight weanling piglets and an equal number of IUGR littermates were given a basal diet with or without polydatin (250 mg/kg) ... More
5'ValCAC tRNA fragment generated as part of a protective angiogenin response provides prognostic value in amyotrophic lateral sclerosis.
AuthorsHogg MC,Rayner M,Susdalzew S,Monsefi N,Crivello M,Woods I,Resler A,Blackbourn L,Fabbrizio P,Trolese MC,Nardo G,Bendotti C,van den Berg LH,van Es MA,Prehn JHM
JournalBrain communications
PubMed ID33543130
Loss-of-function mutations in the ribonuclease angiogenin are associated with amyotrophic lateral sclerosis. Angiogenin has been shown to cleave transfer RNAs during stress to produce âtransfer-derived stress-induced RNAsâ. Stress-induced tRNA cleavage is preserved from single-celled organisms to humans indicating it represents part of a highly conserved stress response. However, to date, ... More
Eugenol Induces Apoptosis in Tongue Squamous Carcinoma Cells by Mediating the Expression of Bcl-2 Family.
Head and neck squamous cell carcinoma is highly aggressive type of cancer for which the available treatment often causes patients severe side effects. Eugenol (Eug) is the major active constituent of clove essential oil and is known to possess antitumor properties. The present study aimed to assess the in vitro ... More
Neuroprotective Effect of IND1316, an Indole-Based AMPK Activator, in Animal Models of Huntington Disease.
Aggregation of mutant huntingtin, due to an expanded polyglutamine track, underlies the cause of neurodegeneration in Huntington disease (HD). However, it remains unclear how some alterations at the cellular level lead to specific structural changes in HD brains. In this context, the neuroprotective effect of the activation of AMP-activated protein ... More
Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human.
Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD) and is characterized by inflammation, hepatocyte injury, and fibrosis. Further, NASH is a risk factor for cirrhosis and hepatocellular carcinoma. Previous research demonstrated that serum N-glycan profiles can be altered in NASH patients. Here, we hypothesized that ... More
Multiple Novel Human Norovirus Recombinants Identified in Wastewater in Pretoria, South Africa by Next-Generation Sequencing.
The genogroup II genotype 4 (GII.4) noroviruses are a major cause of viral gastroenteritis. Since the emergence of the Sydney_2012 variant, no novel norovirus GII.4 variants have been reported. The high diversity of noroviruses and periodic emergence of novel strains necessitates continuous global surveillance. The aim of this study was ... More
Pregnane X Receptor‒4β-Hydroxycholesterol Axis in the Regulation of Overweight- and Obesity-Induced Hypertension.
BACKGROUND: Mechanisms mediating hypertensive effects of overweight and obesity have not been fully elucidated. We showed previously that activation of pregnane X receptor (PXR) by rifampicin elevates 24âhour blood pressure (BP) and plasma 4βâhydroxycholesterol (4βHC), agonist for liver X receptor (LXR). METHODS AND RESULTS: In combined âPXR activation data setâ ... More
Green-Based Approach to Synthesize Silver Nanoparticles Using the Fungal Endophyte Penicillium oxalicum and Their Antimicrobial, Antioxidant, and In Vitro Anticancer Potential.
AuthorsGupta P,Rai N,Verma A,Saikia D,Singh SP,Kumar R,Singh SK,Kumar D,Gautam V
JournalACS omega
PubMed ID36570288
[Image: see text] A green-based approach for the synthesis of silver nanoparticles has gained tremendous attention in biomedical applications. Fungal endophytes have been recognized as a remarkable biological source for the synthesis of potential nanodrugs. The present study focuses on the fabrication of silver nanoparticles using the fungal endophyte Penicillium ... More