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Bethyl Laboratories
USP34 Polyclonal Antibody
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Product Details
A300-824A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 3350 and the C-terminus (residue 3395) of Human Ubiquitin Specific Protease 34.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Target Information
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 34; U2af1-rs1 region 2; Ubiquitin carboxyl-terminal hydrolase 34; ubiquitin specific protease 34; Ubiquitin thioesterase 34; ubiquitin thiolesterase 34; Ubiquitin-specific-processing protease 34; unnamed protein product
Gene Aliases: A530081C03Rik; KIAA0570; KIAA0729; Murr2; USP34
UniProt ID: (Human) Q70CQ2, (Mouse) Q6ZQ93
Entrez Gene ID: (Human) 9736, (Mouse) 17847
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
non-receptor serine/threonine protein kinase
protein modifying enzyme
proteolysis
regulation of signal transduction
Wnt signaling pathway
protein deubiquitination
regulation of protein stability
post-translational protein modification
protein K48-linked deubiquitination
positive regulation of canonical Wnt signaling pathway
ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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