Heterogeneous nuclear ribonucleoprotein (hnRNP) E1 binds to hnRNP A2 and inhibits translation of A2 response element mRNAs.
AuthorsKosturko LD, Maggipinto MJ, Korza G, Lee JW, Carson JH, Barbarese E
JournalMol Biol Cell
PubMed ID16775011
'Heterogeneous nuclear ribonucleoprotein (hnRNP) A2 is a trans-acting RNA-binding protein that mediates trafficking of RNAs containing the cis-acting A2 response element (A2RE). Previous work has shown that A2RE RNAs are transported to myelin in oligodendrocytes and to dendrites in neurons. hnRNP E1 is an RNA-binding protein that regulates translation of ... More
CR1-mediated ATP Release by Human Red Blood Cells Promotes CR1 Clustering and Modulates the Immune Transfer Process.
AuthorsMelhorn MI, Brodsky AS, Estanislau J, Khoory JA, Illigens B, Hamachi I, Kurishita Y, Fraser AD, Nicholson-Weller A, Dolmatova E, Duffy HS, Ghiran IC,
Journal
PubMed ID24022490
'Humans and other higher primates are unique among mammals in using complement receptor 1 (CR1, CD35) on red blood cells (RBC) to ligate complement-tagged inflammatory particles (immune complexes, apoptotic/necrotic debris, and microbes) in the circulation for quiet transport to the sinusoids of spleen and liver where resident macrophages remove the ... More
Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish.
AuthorsCianciolo Cosentino C, Berto A, Pelletier S, Hari M, Loffing J, Neuhauss SCF, Doye V
JournalSci Rep
PubMed ID30894603
'Although structural nuclear pore proteins (nucleoporins) are seemingly required in every cell type to assemble a functional nuclear transport machinery, mutations or deregulation of a subset of them have been associated with specific human hereditary diseases. In particular, previous genetic studies of patients with nephrotic syndrome identified mutations in Nup107 ... More
Combined Structural and Functional Imaging of the Kidney Reveals Major Axial Differences in Proximal Tubule Endocytosis.
Authors
JournalJ Am Soc Nephrol
PubMed ID30301861
Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex.
AuthorsPark T, Kim JY, Cho H, Moon HC, Kim BJ, Park JH, Hong D, Park J, Choi IS
JournalPolymers (Basel)
PubMed ID30970819
'The blood-type-mismatch problem, in addition to shortage of blood donation, in blood transfusion has prompted the researchers to develop universal blood that does not require blood typing. In this work, the "cell-in-shell" (i.e., artificial spore) approach is utilized to shield the immune-provoking epitopes on the surface of red blood cells ... More
Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish.
Authors
JournalCell Syst
PubMed ID31445892
Therapy with 2'-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption.
Authors
JournalMol Ther Nucleic Acids
PubMed ID31610379
Synaptic activity controls autophagic vacuole motility and function in dendrites.
Authors
JournalJ Cell Biol
PubMed ID33783472
Adsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregation.
Authors
JournalACS Nano
PubMed ID26751094
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Authors
JournalCancer Discov
PubMed ID28899863
Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke.
Authors
JournalActa Neuropathol
PubMed ID35752654
Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes.
Authors
JournalElife
PubMed ID32191206
Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis.
Authors
JournalEMBO Mol Med
PubMed ID34165243
Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney.
Authors
JournalNat Commun
PubMed ID29323117
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
Neutrophils are attracted to and generate dense swarms at sites of cell damage in diverse tissues, often extending the local disruption of organ architecture produced by the initial insult. Whether the inflammatory damage resulting from such neutrophil accumulation is an inescapable consequence of parenchymal cell death has not been explored. ... More
Iron gall ink revisited: hierarchical formation of Fe(iii)-tannic acid coacervate particles in microdroplets for protein condensation.
AuthorsKim BJ, Lee JK, Choi IS
JournalChem Commun (Camb)
PubMed ID30607413
Inspiration from the iron gall ink leads to the efficient formation of Fe(iii)-tannic acid coacervate particles inside the phase-separated microdroplets that are derived from the aqueous PEG/dextran liquid-liquid phase separation system. This hierarchical self-assembly, in aid of the protein affinity of tannic acid, makes it possible to compartmentalize and condense ... More
Detailed cellular assessment of albumin-bound oligonucleotides: Increased stability and lower non-specific cell uptake.
AuthorsLacroix A, Fakih HH, Sleiman HF
JournalJ Control Release
PubMed ID32330572
Conjugation of lipid moieties to nucleic-acid therapeutics increases their interaction with cellular membranes, enhances their uptake and influences in vivo distribution. Once injected in biological fluids, such modifications trigger the binding of various serum proteins, which in turn play a major role in determining the fate of oligonucleotides. Yet, the ... More