Cell mechanics control rapid transitions between blebs and lamellipodia during migration.
AuthorsBergert M, Chandradoss SD, Desai RA, Paluch E,
JournalProc Natl Acad Sci U S A
PubMed ID22786929
Protrusion formation is an essential step during cell migration. Cells migrating in three-dimensional environments and in vivo can form a wide variety of protrusion types, including actin polymerization-driven lamellipodia, and contractility-driven blebs. The ability to switch between different protrusions has been proposed to facilitate motility in complex environments and to ... More
A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish.
AuthorsLiu J, Fraser SD, Faloon PW, Rollins EL, Vom Berg J, Starovic-Subota O, Laliberte AL, Chen JN, Serluca FC, Childs SJ,
JournalProc Natl Acad Sci U S A
PubMed ID17573532
The vasculature tailors to the needs of different tissues and organs. Molecular, structural, and functional specializations are observed in different vascular beds, but few genetic models give insight into how these differences arise. We identify a unique cerebrovascular mutation in the zebrafish affecting the integrity of blood vessels supplying the ... More
Measuring molecular rupture forces between single actin filaments and actin-binding proteins.
AuthorsFerrer JM, Lee H, Chen J, Pelz B, Nakamura F, Kamm RD, Lang MJ,
JournalProc Natl Acad Sci U S A
PubMed ID18591676
Actin-binding proteins (ABPs) regulate the assembly of actin filaments (F-actin) into networks and bundles that provide the structural integrity of the cell. Two of these ABPs, filamin and alpha-actinin, have been extensively used to model the mechanical properties of actin networks grown in vitro; however, there is a lack in ... More
Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.
Authors
JournalActa Neuropathol
PubMed ID26687981
Therapy with Multipotent Mesenchymal Stromal Cells Protects Lungs from Radiation-Induced Injury and Reduces the Risk of Lung Metastasis.
Authors
JournalAntioxid Redox Signal
PubMed ID26066676
FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer.
Authors
JournalCell Rep
PubMed ID35385742
Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.
Authors
JournalNat Med
PubMed ID32514169
Magnetically attachable stencils and the non-destructive analysis of the contribution made by the underlying matrix to cell migration.
Authors
JournalBiomaterials
PubMed ID22940214
Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes.
Authors
JournalElife
PubMed ID32191206
Endothelial EphB4 maintains vascular integrity and transport function in adult heart.
Authors
JournalElife
PubMed ID31782728
Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation.
Authors
JournalNeuron
PubMed ID28334606
3D projection electrophoresis for single-cell immunoblotting.
Authors
JournalNat Commun
PubMed ID33277486
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease.