4'-Methoxychalcone, 97%
4'-Methoxychalcone, 97%
4'-Methoxychalcone, 97%
Thermo Scientific Chemicals

4'-Methoxychalcone, 97%

CAS: 959-23-9 | C16H14O2 | 238.286 g/mol
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5 g
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100 g
Catalog number B22158.22
also known as B22158-22
Price (EUR)
243,00
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Quantity:
100 g
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Price (EUR)
243,00
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Chemical Identifiers
CAS959-23-9
IUPAC Name(2E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one
Molecular FormulaC16H14O2
InChI KeyKJHHAPASNNVTSN-KPKJPENVSA-N
SMILESCOC1=CC=C(C=C1)C(=O)C=CC1=CC=CC=C1
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SpecificationsSpecification SheetSpecification Sheet
Assay (GC)≥96.0%
Appearance (Color)White to pale cream to pale yellow
Identification (FTIR)Conforms
Melting Point (clear melt)102.0-111.0?C
FormCrystals or powder or crystalline powder
4-Methoxychalcone is used as a precursor to prepare 3-(4-methoxy-phenyl)-3-morpholin-4-yl-1-phenyl-propan-1-one by reacting with morpholine in presence of heptanes as solvent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Methoxychalcone is used as a precursor to prepare 3-(4-methoxy-phenyl)-3-morpholin-4-yl-1-phenyl-propan-1-one by reacting with morpholine in presence of heptanes as solvent.

Solubility
Soluble in dichloromethane and methanol. Insoluble in water.

Notes
Keep the container tightly closed in a dry and well-ventilated place. Incompatible withstrong oxidizing agents.
RUO – Research Use Only

General References:

  1. Lee, D. S.; Li, B.; Im, N. K.; Kim, Y. C.; Jeong, G. S. 4,2',5'-Trihydroxy-4'-methoxychalcone from Dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages. Int. Immunopharmacol. 2013, 16 (1), 114-121.
  2. Lim, J.; Lee, S. H.; Cho, S.; Lee, I. S.; Kang, B. Y.; Choi, H. J. 4-methoxychalcone enhances cisplatin-induced oxidative stress and cytotoxicity by inhibiting the Nrf2/ARE-mediated defense mechanism in A549 lung cancer cells. Mol. Cells 2013, 36 (4), 340-346.