4-Bromomethyl-3-nitrobenzoic acid is used as a reactant in the synthesis of 4-bromomethyl-3-nitrobenzoic acid succinimide ester, 4-((2-(hydroxymethyl)phenyl amino)methyl)-3-nitrobenzoic acid, 4-(2-hydroxyethylmercaptylmethyl)-3-nitrobenzoic acid. It is also used as a thiol photo-deprotection reagent, a starting material in the synthesis of 2H-indazole based library using parallel solution-phase methods.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4-Bromomethyl-3-nitrobenzoic acid is used as a reactant in the synthesis of 4-bromomethyl-3-nitrobenzoic acid succinimide ester, 4-((2-(hydroxymethyl)phenyl amino)methyl)-3-nitrobenzoic acid, 4-(2-hydroxyethylmercaptylmethyl)-3-nitrobenzoic acid. It is also used as a thiol photo-deprotection reagent, a starting material in the synthesis of 2H-indazole based library using parallel solution-phase methods.
Solubility
Soluble in DMF and dichloromethane. Insoluble in water.
Notes
Store in a cool, dry conditions, in well sealed conditions. Store away from oxidizing agents, bases.
RUO – Research Use Only
General References:
- G Marriott; H Miyata; K Kinosita. Photomodulation of the nucleating activity of a photocleavable crosslinked actin dimer. Biochemistry international. Commun. 1992, 26 (5), 943-951.
- Eric Besson; Anne-Marie Gue; Jan Sudor; Hafsa Korri-Youssoufi; Nicole Jaffrezic; Jacques Tardy. A novel and simplified procedure for patterning hydrophobic and hydrophilic SAMs for microfluidic devices by using UV photolithography. Langmuir. 2006, 22 (20), 8346-8352.