Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a ß-cyclodextrin.
AuthorsMaulik M, Ghoshal B, Kim J, Wang Y, Yang J, Westaway D, Kar S,
JournalHum Mol Genet
PubMed ID22869680
'Niemann-Pick type C (NPC) disease, an autosomal recessive disorder caused primarily by loss-of-function mutations in NPC1 gene, is characterized neuropathologically by intracellular cholesterol accumulation, gliosis and neuronal loss in selected brain regions. Recent studies have shown that NPC disease exhibits intriguing parallels with Alzheimer''s disease (AD), including the presence of ... More
The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memory.
'The central nucleus of the amygdala (CeA) has been traditionally viewed in fear conditioning to serve as an output neural center that transfers conditioned information formed in the basolateral amygdala to brain structures that generate emotional responses. Recent studies suggest that the CeA may also be involved in fear memory ... More
Srgap3?/? mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes.
AuthorsWaltereit R, Leimer U, von Bohlen Und Halbach O, Panke J, Hölter SM, Garrett L, Wittig K, Schneider M, Schmitt C, Calzada-Wack J, Neff F, Becker L, Prehn C, Kutscherjawy S, Endris V, Bacon C, Fuchs H, Gailus-Durner V, Berger S, Schönig K, Adamski J, Klopstock T, Esposito I, Wurst W, de Angelis MH, Rappold G, Wieland T, Bartsch D,
JournalFASEB J
PubMed ID22820399
Mutations in the SRGAP3 gene residing on chromosome 3p25 have previously been associated with intellectual disability. Genome-wide association studies have also revealed SRGAP3, together with genes from the same cellular network, as risk genes for schizophrenia. SRGAP3 regulates cytoskeletal dynamics through the RHO protein RAC1. RHO proteins are known to ... More
Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons.
Authors
JournalElife
PubMed ID34240706
A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition.
Authors
JournalNeurotherapeutics
PubMed ID33118131
Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth.
Authors
JournalElife
PubMed ID31909712
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development.