Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors.
AuthorsBianchetti E, Bates SJ, Carroll SL, Siegelin MD, Roth KA,
JournalSci Rep
PubMed ID30478285
'Malignant peripheral nerve sheath tumors (MPNSTs) are the leading cause of death in neurofibromatosis type 1 (NF1) patients. Current treatment modalities have been largely unsuccessful in improving MPNST patient survival, making the identification of new therapeutic targets urgent. In this study, we found that interference with Usp9X, a deubiquitinating enzyme ... More
Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer.
'Host responses to tumor cells include tumor suppressing or promoting mechanisms. We sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the mammary tumor immune portfolio. We hypothesized that Hh signaling mediates a crosstalk between breast cancer cells and macrophages that dictates alternative polarization of ... More
The structural atrophy of the aneurysm wall in secondary expanding aortic aneurysms with endoleak type II.
AuthorsMenges AL, Busch A, Reutersberg B, Trenner M, Kath P, Chernogubova E, Maegdefessel L, Eckstein HH, Zimmermann A
JournalJ Vasc Surg
PubMed ID30792063
'Abdominal aortic aneurysm (AAA) has an age-dependent prevalence of 2% to 11% and is a leading cause of death in men aged >65 years if not treated surgically. Today, endovascular aneurysm repair (EVAR) is performed in up to 80% of elective cases and 60% of ruptured cases. Although EVAR improves perioperative, ... More
Anti-tumor effect of cisplatin in human oral squamous cell carcinoma was enhanced by andrographolide via upregulation of phospho-p53 in vitro and in vivo.
'Oral squamous cell carcinoma is one of the most common neoplasm in the world. Despite the improvements in diagnosis and treatment, the outcome is still poor now. Thus, the development of novel therapeuticapproaches is needed. The aim of this study is to assess the synergistic anti-tumor effect of andrographolide with ... More
Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma.
AuthorsCheng Y, Luo R, Zheng H, Wang B, Liu Y, Liu D, Chen J, Xu W, Li A, Zhu Y,
JournalOncotarget
PubMed ID28423574
Drug resistance to sorafenib is common in patients with hepatocellular carcinoma(HCC). We examined the effects of a combination of sorafenib and fluvastatin on HCC using in vitro and in vivo models. The dual treatment induced apoptosis and reduced cellular viability in HCC more effectively than either drug alone. The combination ... More
Soybean Oil-Derived Poly-Unsaturated Fatty Acids Enhance Liver Damage in NAFLD Induced by Dietary Cholesterol.
AuthorsHenkel J, Alfine E, Saín J, Jöhrens K, Weber D, Castro JP, König J, Stuhlmann C, Vahrenbrink M, Jonas W, Kleinridders A, Püschel GP,
JournalNutrients
PubMed ID30231595
While the impact of dietary cholesterol on the progression of atherosclerosis has probably been overestimated, increasing evidence suggests that dietary cholesterol might favor the transition from blunt steatosis to non-alcoholic steatohepatitis (NASH), especially in combination with high fat diets. It is poorly understood how cholesterol alone or in combination with ... More
Melittin induces NSCLC apoptosis via inhibition of miR-183.
AuthorsGao D, Zhang J, Bai L, Li F, Dong Y, Li Q,
JournalOnco Targets Ther
PubMed ID30122943
Non-small-cell lung cancer (NSCLC) has one of the highest mortality rates among cancers worldwide, with a poor prognosis. Previous studies have reported that melittin, an active component of apitoxin, exerts anti-inflammatory and antitumor effects via vascular endothelial growth factor or FoxO1. CCK8, flow cytometry assay and Western blotting were performed ... More
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
AuthorsLiang X, Ding Y, Lin F, Zhang Y, Zhou X, Meng Q, Lu X, Jiang G, Zhu H, Chen Y, Lian Q, Fan H, Liu Z
JournalFASEB J
PubMed ID30566395
The age-related functional exhaustion limits potential efficacy of mesenchymal stem cells (MSC) in treating cardiovascular disease. Therefore, rejuvenation of aged MSC in the elderly population is of great interest. We have previously reported that Erb-B2 receptor tyrosine kinase 4 ( ERBB4) plays a critical role in regulating MSC survival under ... More
Antioxidant Enzymes Expression of the Impaired Contralateral Testes in Unilaterally Cryptorchid Rats.
AuthorsZhu BP, Cai L
JournalCrit Rev Eukaryot Gene Expr
PubMed ID31679267
In this study, explored the pathologic mechanism of the contralateral testes impairment in unilaterally cryptorchid rats by investigating the gene expression level.
Daratumumab-
AuthorsDawicki W, Allen KJH, Jiao R, Malo ME, Helal M, Berger MS, Ludwig DL, Dadachova E
JournalOncoimmunology
PubMed ID31413916
Daratumumab is an anti-CD38 directed monoclonal antibody approved for the treatment of multiple myeloma (MM) and functions primarily via Fc-mediated effector mechanisms such as complement-dependent cytotoxicity (CDC), antibody-dependent cell cytotoxicity (ADCC), antibody-dependent cellular phagocytosis, and T-cell activation. However, not all patients respond to daratumumab therapy and management of MM remains ... More
Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis.
AuthorsQian YC, Xie YX, Wang CS, Shi ZM, Jiang CF, Tang YY, Qian X, Wang L, Jiang BH,
JournalAsian J Androl
PubMed ID31489847
The apoptosis that occurs in the immature testis under physiological conditions is necessary for male germ cell development, whereas improper activation of apoptosis can impair spermatogenesis and cause defects in reproduction. We previously demonstrated that in mice, the makorin-2 (Mkrn 2) gene is expressed exclusively in the testis and its ... More
lncRNA CCAT2 promotes radiotherapy resistance for human esophageal carcinoma cells via the miR-145/p70S6K1 and p53 pathway.
AuthorsWang M, Wang L, He X, Zhang J, Zhu Z, Zhang M, Li X
JournalInt J Oncol
PubMed ID31789385
The long non-coding RNA colon cancer-associated transcript 2 (CCAT2) is abnormally expressed in various types of malignant tumor tissues and considered to be an oncogene, including for esophageal cancer (EC). Radiotherapy is an important and widely used cancer treatment. However, some patients with EC do not respond to radiotherapy. This study ... More
miR-137 targets the inhibition of TCF4 to reverse the progression of osteoarthritis through the AMPK/NF-?B signaling pathway.
AuthorsWang J, Fang L, Ye L, Ma S, Huang H, Lan X, Ma J
JournalBiosci Rep
PubMed ID32432314
To explore the regulatory mechanism of miR-137 and transcription factor 4 (TCF4) in the progression of osteoarthritis (OA).