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OriGene
HSD17B10 Monoclonal Antibody (OTI3B5), TrueMAB™
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FIGURE: 1 / 1
HSD17B10 Antibody (CF500687) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HSD17B10 (RC201734, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-HS. Positive lysates LY401426 (100 µg) and LC401426 (20 µg) can be purchased separately from OriGene.
Product Details
CF500687
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3B5
Immunogen
Full-length protein expressed in 293T cell transfected with human HSD17B10 expression vector
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17-beta-estradiol 17-dehydrogenase; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3-hydroxyacyl-CoA dehydrogenase type-2; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; AB-binding alcohol dehydrogenase; amyloid-beta peptide binding alcohol dehydrogenase; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; HADH2; HADH2 protein; hydroxysteroid (17-beta) dehydrogenase 10 isoform HSD17B10_1; hydroxysteroid (17-beta) dehydrogenase 10 isoform HSD17B10_2; MHBD; mitochondrial ribo; Mitochondrial ribonuclease P protein 2; mitochondrial RNas; Mitochondrial RNase P protein 2; mitochondrial RNase P subunit 2; RP3-339A18.2; Short chain dehydrogenase/reductase family 5C member 1; short chain L-3-hydroxyacyl-CoA dehydrogenase type 2; short chain type dehydrogenase/reductase XH98G2; Short-chain type dehydrogenase/reductase XH98G2; type 10 17b-HSD; Type II HADH; X-linked alcohol dehydrogenase
Gene Aliases: 17b-HSD10; ABAD; CAMR; DUPXp11.22; ERAB; HADH2; HCD2; HSD10MD; HSD17B10; MHBD; MRPP2; MRX17; MRX31; MRXS10; SCHAD; SDR5C1; XH98G2
UniProt ID: (Human) Q99714
Entrez Gene ID: (Human) 3028
tRNA binding
RNA binding
3-hydroxyacyl-CoA dehydrogenase activity
estradiol 17-beta-dehydrogenase activity
protein binding
cholate 7-alpha-dehydrogenase activity
oxidoreductase activity
testosterone dehydrogenase [NAD(P)] activity
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
testosterone dehydrogenase (NAD+) activity
androstan-3-alpha,17-beta-diol dehydrogenase activity
chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
isoleucine catabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid beta-oxidation
bile acid biosynthetic process
mitochondrion organization
tRNA processing
steroid metabolic process
C21-steroid hormone metabolic process
androgen metabolic process
estrogen metabolic process
protein homotetramerization
brexanolone metabolic process
mitochondrial tRNA methylation
mitochondrial tRNA 5'-end processing
mitochondrial tRNA 3'-end processing
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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