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OriGene
CYP2E1 Monoclonal Antibody (OTI5B9), TrueMAB™
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Product Details
CF500734
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5B9
Immunogen
Full length human recombinant protein of human CYP2E1 produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4-nitrophenol 2-hydroxylase; CP2E1; CYPIIE1; Cytochrome P450 2E1; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; Cytochrome P450-J; cytochrome P450A; cytochrome P450j; flavoprotein-linked monooxygenase; microsomal monooxygenase; microsomal monooxygenase; xenobiotic monooxygenase; unnamed protein product; xenobiotic monooxygenase
Gene Aliases: CPE1; CYP2E; CYP2E1; P450-J; P450C2E
UniProt ID: (Human) P05181
Entrez Gene ID: (Human) 1571
monooxygenase activity
iron ion binding
arachidonic acid epoxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
4-nitrophenol 2-monooxygenase activity
oxygen binding
enzyme binding
heme binding
Hsp70 protein binding
metal ion binding
Hsp90 protein binding
long-chain fatty acid omega-1 hydroxylase activity
long-chain fatty acid metabolic process
lipid hydroxylation
lipid metabolic process
fatty acid metabolic process
xenobiotic metabolic process
steroid metabolic process
response to bacterium
monoterpenoid metabolic process
carbon tetrachloride metabolic process
benzene metabolic process
4-nitrophenol metabolic process
epoxygenase P450 pathway
halogenated hydrocarbon metabolic process
long-chain fatty acid biosynthetic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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