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PPARA Monoclonal Antibody (OTI2F3), TrueMAB™

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PPARA Monoclonal Antibody (OTI2F3), TrueMAB™

Product Details

CF503542

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI2F3

Immunogen

Human recombinant protein fragment corresponding to amino acids 145-420 of human PPARA produced in E.coli.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR's can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with retinoid X receptor (RXR) alpha.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC2237; MGC2452; Nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator; peroxisome proliferator activated receptor; Peroxisome proliferator-activated receptor alpha; PPAR-alpha; PPARA; PPARalpha; unnamed protein product

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Gene Aliases: hPPAR; NR1C1; PPAR; PPAR-alpha; PPARA; PPARalpha

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UniProt ID: (Human) Q07869

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Entrez Gene ID: (Human) 5465

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding lipid binding phosphatase binding protein domain specific binding mitogen-activated protein kinase kinase kinase binding ubiquitin conjugating enzyme binding signaling receptor activity sequence-specific DNA binding macromolecular complex binding metal ion binding NFAT protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding MDM2/MDM4 family protein binding DNA-binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia gluconeogenesis regulation of transcription, DNA-templated lipid metabolic process fatty acid metabolic process heart development response to nutrient lactation epidermis development cellular response to starvation hormone-mediated signaling pathway gene expression regulation of gene expression regulation of cellular ketone metabolic process negative regulation of macrophage derived foam cell differentiation negative regulation of cholesterol storage regulation of fatty acid metabolic process cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway intracellular steroid hormone receptor signaling pathway intracellular receptor signaling pathway positive regulation of fatty acid beta-oxidation negative regulation of appetite response to insulin circadian regulation of gene expression behavioral response to nicotine peroxisome proliferator activated receptor signaling pathway wound healing lipoprotein metabolic process regulation of circadian rhythm response to ethanol positive regulation of gluconeogenesis negative regulation of blood pressure negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of transcription from RNA polymerase II promoter nitric oxide metabolic process positive regulation of fatty acid oxidation positive regulation of lipid biosynthetic process rhythmic process negative regulation of inflammatory response negative regulation of protein kinase B signaling negative regulation of cell growth involved in cardiac muscle cell development enamel mineralization cellular response to fructose stimulus negative regulation of cytokine production involved in inflammatory response negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of leukocyte cell-cell adhesion negative regulation of reactive oxygen species biosynthetic process negative regulation of hepatocyte apoptotic process positive regulation of transformation of host cell by virus regulation of fatty acid transport positive regulation of ATP biosynthetic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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