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OriGene
SMAD1 Monoclonal Antibody (OTI1C5), TrueMAB™
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Product Details
CF507244
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1C5
Immunogen
Full length human recombinant protein of human SMAD1 produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BSP-1; DWFC; hSMAD1; JV4-1; JV5-1; MAD homolog 1; MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; MADH5; Mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; Mothers-against-DPP-related-1; OTTHUMP00000220456; Sma and Mad homolog; SMAD; SMAD 1; SMAD family member 1; SMAD, mothers against DPP homolog 1; SMAD5; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1; unnamed protein product
Gene Aliases: BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1; SMAD1
UniProt ID: (Human) Q15797
Entrez Gene ID: (Human) 4086
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
DEAD/H-box RNA helicase binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
sequence-specific DNA binding
metal ion binding
co-SMAD binding
I-SMAD binding
primary miRNA binding
MAPK cascade
ossification
osteoblast differentiation
ureteric bud development
mesodermal cell fate commitment
osteoblast fate commitment
cardiac conduction system development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular iron ion homeostasis
inflammatory response
signal transduction
transforming growth factor beta receptor signaling pathway
gamete generation
cell proliferation
negative regulation of cell proliferation
anatomical structure morphogenesis
embryonic pattern specification
positive regulation of gene expression
cell differentiation
BMP signaling pathway
midbrain development
hindbrain development
primary miRNA processing
developmental process
homeostatic process
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
negative regulation of muscle cell differentiation
cartilage development
cardiac muscle cell proliferation
bone development
SMAD protein signal transduction
positive regulation of cartilage development
cellular response to growth factor stimulus
transforming growth factor beta receptor superfamily signaling pathway
positive regulation of dendrite development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of sprouting angiogenesis
anti-Mullerian hormone signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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