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OriGene
VAPB Monoclonal Antibody (OTI4D8), TrueMAB™
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FIGURE: 1 / 1
VAPB Antibody (CF808674) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY VAPB (RC200517, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-VAPB. (1. Positive lysates LY401498 (100 µg) and LC401498 (20 µg) can be purchased separately from OriGene.
Product Details
CF808674
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4D8
Immunogen
Human recombinant protein fragment corresponding to amino acids 2-223 of human VAPB produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Vesicle-associated membrane protein-associated protein B/C is a protein that in humans is encoded by the VAPB gene. The VAPB gene is found on the 20th human chromosome. The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALS 8; ALS8VAMP-B/VAMP-C; splice variant of VAPB; unnamed protein product; vamp; VAMP (vesicle-associated membrane protein)-associated protein B and C; Vamp 33b; VAMP B; VAMP B VAMP C; VAMP B/VAMP C; VAMP C; VAMP-associated 33 kDa protein; VAMP-associated protein 33b; VAMP-associated protein B; VAMP-B; VAMP-B/VAMP-C; VAMP-C; VAMPB; VAMPB/VAMPC; VAMPC; VAP 33b; VAP B; VAP B/VAP C; VAP C; VAP-33; VAP-B; VAP-B/VAP-C; VAP-C; VAPB/VAPC; VAPC; vesicle-associated membrane protein, associated protein B and C; Vesicle-associated membrane protein-associated protein B; Vesicle-associated membrane protein-associated protein B/C
Gene Aliases: AI225786; AI840687; AI848259; ALS8; D2Abb2e; R75548; UNQ484/PRO983; VAMP-B; Vamp33b; VAP-B; VAP33b; VAPB
UniProt ID: (Human) O95292, (Rat) Q9Z269
Entrez Gene ID: (Human) 9217, (Rat) 60431, (Mouse) 56491
cellular calcium ion homeostasis
ER to Golgi vesicle-mediated transport
response to unfolded protein
endoplasmic reticulum organization
viral release from host cell
cholesterol transport
endoplasmic reticulum unfolded protein response
IRE1-mediated unfolded protein response
negative regulation by host of viral release from host cell
negative regulation by host of viral genome replication
positive regulation by host of viral genome replication
modulation by host of viral RNA genome replication
positive regulation of viral genome replication
negative regulation by virus of viral protein levels in host cell
endoplasmic reticulum-plasma membrane tethering
COPII-coated vesicle budding
endoplasmic reticulum membrane organization
activation of signaling protein activity involved in unfolded protein response
biological_process
modulation by virus of host morphology or physiology
positive regulation by host of viral release from host cell
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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