The Thermo Scientific DynaDrive Single-Use Bioreactor (S.U.B.) drives bioprocessing efficiency and allows users to reimagine bioreactor possibilities. The DynaDrive S.U.B. utilizes a revolutionary stir-tank design to meet cell culture demands of today and the future. The DynaDrive S.U.B. not only offers the advantages of single use, but also provides the mixing and mass transfer performance that demanding cell lines require. The hardware, mixing impeller (drive train), and sparging approach have been redesigned to optimize mixing dynamics, scale, and performance. The DynaDrive technology allows for lower seed-train turndown ratios, which facilitates efficiencies and reduces risk of contamination. The complete line of DynaDrive S.U.B.s include 50, 500, 3000, and 5000 L sizes that ensure consistent scalability from pilot-scale studies to pre-clinical to commercial production. The DynaDrive technology brings single-use to unprecedented volumes and performance.

Features:
• Hardware is jacketed with load cells
• Optimal-precision load cells
• Large volume—50 L, 500 L, 3000 L, and 5,000 L; working volume options available
• Improved seed train process
   --50 L: 10:1 turndown ratio; seed with as little as 5 L
   --500 L: 20:1 turndown ratio; seed with as little as 25 L
   --3000 L: 12.5:1 turndown ratio; seed with as little as 250 L
   --5000 L: 20:1 turndown ratio; seed with as little as 250 L
• Mixing times, power input per volume (PIV), and kLa performance are optimized for modern cell culture processes with >100 million cells/mL
• Hardware optimized for perfusion cell culture processes
• Ergonomically friendly hardware—designed with the user in mind and allows for consistent and uniform bioprocess container (BPC) loading
   --All BPC connections done at ground level and BPC deployed automatically with a lift mechanism
• Open-architecture approach—allows interoperability with available control systems
• DynaDrive BPCs with integrated drive train and made with highly robust Thermo Scientific Aegis 5-14 bioprocessing film
• BPC film and components subjected to leachable and extractable (L&E) evaluation according to BioPhorum Operations Group (BPOG) guidelines

Applications of the Thermo Scientific DynaDrive S.U.B. include:
• Batch, fed batch, and perfusion cultures