Cellular immune responses of schistosomiasis patients are altered by human immunodeficiency virus type 1 coinfection.
AuthorsMwinzi PN, Karanja DM, Colley DG, Orago AS, Secor WE
JournalJ Infect Dis
PubMed ID11471107
'In vitro studies suggest that CD4(+) cells with a T helper 2 (Th2) phenotype better support human immunodeficiency virus type 1 (HIV-1) replication than do cells of the Th1 phenotype. As a result, Th2-type immune responses may be substantially affected by HIV-1 coinfection. To test this hypothesis, a comparison was ... More
Bi-directional modulation of T cell-dependent antibody production by prostaglandin E(2).
AuthorsHe X, Weyand CM, Goronzy JJ, Zhong W, Stuart JM
JournalInt Immunol
PubMed ID11751754
'T cell-dependent Ig production involves interaction between T cells and B cells. This study evaluated the effects of prostaglandin (PG) E(2) on Ig production in a system in which B cells were co-cultured with autologous CD4(+) T cell clones non-specifically activated by anti-CD3. The effects of PGE(2) on T cell-dependent ... More
Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis.
AuthorsBuckner JH, Van Landeghen M, Kwok WW, Tsarknaridis L
JournalArthritis Rheum
PubMed ID11817597
'To characterize and clone T cells specific for type II collagen (CII) in a patient with relapsing polychondritis (RP) and to establish whether the immunodominant epitope of CII determined in HLA transgenic mice is used in the human autoimmune response to CII.' ... More
Modulation of T cell response to hGAD65 peptide epitopes.
AuthorsMasewicz SA, Papadopoulos GK, Swanson E, Moriarity L, Moustakas AK, Nepom GT
JournalTissue Antigens
PubMed ID12028536
'Human CD4 T cell responses to an epitope of hGAD65 (GAD = glutamic acid decarboxylase), residues 555-567, are modulated by interaction with an altered peptide ligand containing modifications at TCR contact residues. Using different HLA-DR4 molecules with polymorphisms at sites corresponding to peptide binding pockets p1 and p9, we tested ... More
Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset.
AuthorsCooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA
JournalBlood
PubMed ID11342442
'During the innate immune response to infection, monocyte-derived cytokines (monokines), stimulate natural killer (NK) cells to produce immunoregulatory cytokines that are important to the host''s early defense. Human NK cell subsets can be distinguished by CD56 surface density expression (ie, CD56(bright) and CD56(dim)). In this report, it is shown that ... More
Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis.
AuthorsDuda PW, Schmied MC, Cook SL, Krieger JI, Hafler DA
JournalJ Clin Invest
PubMed ID10749576
'We examined the effect of glatiramer acetate, a random copolymer of alanine, lysine, glutamic acid, and tyrosine, on antigen-specific T-cell responses in patients with multiple sclerosis (MS). Glatiramer acetate (Copaxone) functioned as a universal antigen, inducing proliferation, independent of any prior exposure to the polymer, in T-cell lines prepared from ... More
Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo.
AuthorsBohle B, Zwölfer B, Heratizadeh A, Jahn-Schmid B, Antonia YD, Alter M, Keller W, Zuidmeer L, van Ree R, Werfel T, Ebner C
JournalJ Allergy Clin Immunol
PubMed ID16815162
'The major birch pollen allergen Bet v 1 cross-reacts with homologous food allergens, resulting in IgE-mediated oral allergy syndromes (OASs). To avoid this food, allergy allergologists and guidebooks advise patients to consume birch pollen-related foods after heating.' ... More
Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto's thyroiditis (Th1) and Graves' disease (Th2).
AuthorsPhenekos C, Vryonidou A, Gritzapis AD, Baxevanis CN, Goula M, Papamichail M
JournalNeuroimmunomodulation
PubMed ID15249726
The aim of this study was to document the pattern of immune response, assessed by the measurement of both Th1 and Th2 serum cytokines, in patients suffering from autoimmune thyroid disease and toxic nodular goiter. ... More
Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens.
AuthorsJahn-Schmid B, Radakovics A, Lüttkopf D, Scheurer S, Vieths S, Ebner C, Bohle B
JournalJ Allergy Clin Immunol
PubMed ID15990797
Individuals with birch pollen allergy frequently experience hypersensitivity reactions to certain foods, primarily because of IgE antibodies specific for the major birch pollen allergen Bet v 1 that cross-react with homologous food allergens. ... More
Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus.
The hypothesis was tested in an exploratory study that individuals at high risk of developing Type 1 diabetes mellitus have altered systemic levels of cytokines and chemokines. ... More
Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi.
AuthorsShin SH, Ponikau JU, Sherris DA, Congdon D, Frigas E, Homburger HA, Swanson MC, Gleich GJ, Kita H
JournalJ Allergy Clin Immunol
PubMed ID15577837
Chronic rhinosinusitis (CRS) is one of the most common long-term illnesses in the United States. The etiology of CRS is unknown, and no effective treatment has been established. ... More
Probiotics have a different immunomodulatory potential in vitro versus ex vivo upon oral administration in children with food allergy.
AuthorsFlinterman AE, Knol EF, van Ieperen-van Dijk AG, Timmerman HM, Knulst AC, Bruijnzeel-Koomen CA, Pasmans SG, van Hoffen E
JournalInt Arch Allergy Immunol
PubMed ID17290150
Previous studies suggest that administration of probiotics in vitro can stimulate regulatory and Th1 immune responses. We studied both the in vitro immunological effects of probiotics and the ex vivo immunological effects after oral administration of probiotics in children with food allergy, a Th2-mediated disease. ... More
T-cell recognition and cytokine profile induced by melanocyte epitopes in patients with HLA-DRB1*0405-positive and -negative Vogt-Koyanagi-Harada uveitis.
Vogt-Koyanagi-Harada disease (VKH), an autoimmune disease targeted against melanocytes, is associated with HLA-DRB1*0405. This study was undertaken to analyze T-cell recognition and the cytokine expression profile induced by melanocyte epitopes in HLA-DRB1*0405-positive and -negative patients with VKH uveitis. ... More
Concentrations of gastric mucosal cytokines in children with food allergy and Helicobacter pylori infection.
AuthorsMaciorkowska E, Panasiuk A, Kaczmarsk M
JournalWorld J Gastroenterol
PubMed ID16425379
To measure the concentrations of chosen cytokines in the antrum mucosa depending on the kind of harmful pathogenic factors and to compare the concentrations with the values of controls without allergy and coexisting Helicobacter pylori (H pylori) infection. ... More
Absence of mucosal inflammation in uncomplicated diverticular disease.
AuthorsElli L, Roncoroni L, Bardella MT, Terrani C, Bonura A, Ciulla M, Marconi S, Piodi L
JournalDig Dis Sci
PubMed ID21221786
Uncomplicated diverticular disease is a common condition in patients older than 50 years. Symptoms are aspecific and overlapping with those of irritable bowel syndrome. Nowadays, patients are often treated with antinflammatory drugs (5-aminosalicilic acid). ... More
Association of interleukin-5 and eotaxin with acute exacerbation of asthma.
AuthorsPark SW, Kim DJ, Chang HS, Park SJ, Lee YM, Park JS, Chung IY, Lee JH, Park CS
JournalInt Arch Allergy Immunol
PubMed ID12915771
Airway eosinophilia is frequently observed during acute exacerbation of asthma. Interleukin-5 (IL-5) and eotaxin are directly involved in the airway eosinophilia found in persistent asthma. Interrelation between these cytokines is expected to occur in acute exacerbation of asthma. Thus, we evaluated the relevance of interaction between eotaxin and IL-5 in ... More
Effect of renal cell carcinomas on the development of type 1 T-cell responses.
We reported that in renal cell carcinoma patients with active disease, T-cell reactions to the tumor-associated antigens MAGE-6 and EphA2 are highly skewed toward TH2-type cytokine responses [interleukin (IL) 5]. Herein, we determined whether tumor-derived products, including gangliosides isolated from renal cell carcinoma patients, participate in the down-regulation of type ... More
Cellular immune responses to HPV-18, -31, and -53 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles.
Human papillomavirus-like particles (HPV VLP) are candidate vaccines that have shown to be efficacious in reducing infection and inducing robust antiviral immunity. Neutralizing antibodies generated by vaccination are largely type-specific, but little is known about the type-specificity of cellular immune responses to VLP vaccination. To determine whether vaccination with HPV-16 ... More
Natural killer type 2 bias in remission of multiple sclerosis.
AuthorsTakahashi K, Miyake S, Kondo T, Terao K, Hatakenaka M, Hashimoto S, Yamamura T
JournalJ Clin Invest
PubMed ID11238569
Multiple sclerosis (MS) is an autoimmune disease characterized by clinical relapse and remission. Because of the potential role of natural killer (NK) cells in the regulation of autoimmunity, we have examined cytokine profile and surface phenotype of NK cells in the peripheral blood of MS. Here we demonstrate that NK ... More
A novel approach to specific allergy treatment: the recombinant fusion protein of a bacterial cell surface (S-layer) protein and the major birch pollen allergen Bet v 1 (rSbsC-Bet v 1) combines reduced allergenicity with immunomodulating capacity.
AuthorsBohle B, Breitwieser A, Zwölfer B, Jahn-Schmid B, Sára M, Sleytr UB, Ebner C
JournalJ Immunol
PubMed ID15153479
Counterregulating the disease-eliciting Th2-like immune response of allergen-specific Th lymphocytes by fostering an allergen-specific Th1-like response is a promising concept for future immunotherapy of type I allergy. The use of recombinant allergens combined with more functional adjuvants has been proposed. In this respect, we present a novel approach. The gene ... More
Correlation between eosinophils and protection against reinfection with Schistosoma mansoni and the effect of human immunodeficiency virus type 1 coinfection in humans.
Longitudinal investigations of an adult male population of Kenyan car washers who have heavy and quantifiable occupational exposure to Schistosoma mansoni cercariae revealed that some individuals develop resistance to reinfection while others remain highly susceptible. We sought to characterize immune correlates associated with host protection in this population. Previous studies ... More
Long-term pertussis-specific immunity after primary vaccination with a combined diphtheria, tetanus, tricomponent acellular pertussis, and hepatitis B vaccine in comparison with that after natural infection.
AuthorsEsposito S, Agliardi T, Giammanco A, Faldella G, Cascio A, Bosis S, Friscia O, Clerici M, Principi N
JournalInfect Immun
PubMed ID11401994
The aim of this study was to compare pertussis-specific humoral and cellular immunity in children 5 years after a primary vaccination with a combined diphtheria, tetanus, tricomponent acellular pertussis, and hepatitis B vaccine (DTaP-HBV; InfanrixHepB; SmithKline Beecham) with immunity after natural infection. The subjects were 38 children aged 5 to ... More
A role for IL-10-mediated HLA-DR7-restricted T cell-dependent events in development of the modified Th2 response to cat allergen.
AuthorsReefer AJ, Carneiro RM, Custis NJ, Platts-Mills TA, Sung SS, Hammer J, Woodfolk JA
JournalJ Immunol
PubMed ID14978075
Although high dose exposure to inhaled cat allergen (Fel d 1) can cause a form of tolerance (modified Th2 response), the T cell mechanism for this phenomenon has not been studied. T cell responses to Fel d 1 were characterized in both allergic (IgE(pos)) and modified Th2 (IgE(neg)IgG(pos)) responders as ... More
The modulation of cytokine and IgE production by tumor necrosis factor-beta in atopic dermatitis.
AuthorsJirapongsananuruk O, Donahue HL, Trumble AE, Leung DY
JournalJ Invest Dermatol
PubMed ID10620139
Atopic dermatitis (AD) is associated with increased IL-4, IL-5, and IL-13 but decreased IFN-gamma production. This cytokine profile may account for the atopic features of this illness, including IgE upregulation. Recent studies have demonstrated that tumor necrosis factor (TNF)-beta is produced by Th1-like cells, but the cytokine modulation by TNF-beta ... More