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Thermo Scientific™

TheraPure™ GMP DNase I, RNase-free, 50 U/μL

Catalog number: EN052SKB012
Thermo Scientific™

TheraPure™ GMP DNase I, RNase-free, 50 U/μL

Catalog number: EN052SKB012
Catalog Number
EN052SKB012
Unit Size
50 kU
Price (USD)
Catalog Number
Unit Size
250 kU
Price (USD)
Catalog Number
Unit Size
2500 kU
Price (USD)
Catalog Number
Unit Size
16000 kU
Price (USD)
Catalog NumberUnit SizePrice (USD)
EN052SKB01250 kURequest A Quote
EN052R30SKB001250 kURequest A Quote
EN052SKB0082500 kURequest A Quote
EN052R3AFB01316000 kURequest A Quote
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Thermo Scientific TheraPure GMP* DNase I, RNase-free, is manufactured to ICH Q7 GMP principles and supported by a comprehensive documentation package. It is designed for DNA template removal during the development and manufacturing of mRNA therapeutics and vaccines. As an endonuclease it digests both single- and double-stranded DNA.

Designed for process development and manufacturing
TheraPure GMP DNase I, RNase-free helps accelerate mRNA vaccine and therapeutics production from preclinical development to commercialization by providing:
Quality—meet critical product quality needs to help accelerate therapeutic development and manufacturing
Minimal risk—helps reduce risks in developing therapeutics by utilizing proven products
Technical partnership—partner with expert product and technical support
Secure and consistent supply—count on a secure and stable supply of product at a global scale

Comprehensive quality system
TheraPure GMP DNase I is supported by a extensive quality system and documentation including:
• Manufactured to relevant ICH Q7 GMP guidelines
• Animal-origin free (AOF) manufacturing processes, materials, and facilities
• Validated manufacturing processes and analytical test methods
• Comprehensive impurity profiles
• Verified compendial assays where applicable
• Product stability data
• Tested by analytical methods following ICH Q2 guidelines whenever possible
• Drug master file (DMF)

Enzyme activity
One unit of DNase I completely degrades 1 μg of plasmid DNA in 10 minutes at 37°C. One DNase I unit is equivalent to 0.3 Kunitz unit.

For additional TheraPure GMP products or customization, please visit www.thermofisher.com/therapure.

*TheraPure GMP refers to the quality level of the raw, ancillary, or starting materials to be used for further manufacturing. TheraPure GMP products are manufactured in facilities with ISO 9001–certified quality management systems that operate in accordance with relevant good manufacturing practice (GMP) principles, as outlined in ICH Q7 or equivalent guidance documents or standards.

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.

Specifications

Concentration
50 U/μL
Color
Transparent
Purity
≥95%
pH
7.1 to 7.9
For Use With (Application)
In vitro transcription, DNA template removal
Storage Buffer
50 mM Tris-HCl, pH 7.5, 10 mM CaCl2, 50% glycerol
Expression System
Pichia pastoris
Mass
29 kDa
Enzyme
DNase
Source
Bovine gene
Quantity
50 kU
Product Type
DNase
Product Line
TheraPure™ GMP
Biological Activity
DNase
Form
Liquid

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