Mesenchymal stromal cells isolated from human fetal liver release soluble factors with a potential role in liver tissue repair.
AuthorsChinnici CM, Pietrosi G, Iannolo G, Amico G, Cuscino N, Pagano V, Conaldi PG
Journal
PubMed ID30553176
We isolated a population of proliferating cells from cultured human fetal hepatocytes of 16-22 weeks gestational age. The cells shared a similar phenotype to that of mesenchymal stromal cells (MSCs) according to the International Society for Cellular Therapy (ISCT), including plastic adherence, antigen expression profile, and in vitro multilineage differentiation ... More
Hallmarks of improved immunological responses in the vaccination of more physically active elderly females.
AuthorsWong GCL, Narang V, Lu Y, Camous X, Nyunt MSZ, Carre C, Tan C, Xian CH, Chong J, Chua M, How W, Mok E, Tambyah P, Poidinger M, Abel B, Burdin N, Quemeneur L, Bosco N, Ng TP, Larbi A
Journal
PubMed ID30753128
Physical inactivity is one of the leading contributors to worldwide morbidity and mortality. The elderly are particularly susceptible since the features of physical inactivity overlap with the outcomes of natural aging - including the propensity to develop cardiovascular diseases, cancer, diabetes mellitus, sarcopenia and cognitive impairment. The age-dependent loss of ... More
Chemotherapy of colorectal liver metastases induces a rapid rise in intermediate blood monocytes which predicts treatment response.
AuthorsSchauer D, Starlinger P, Alidzanovic L, Zajc P, Maier T, Feldman A, Padickakudy R, Buchberger E, Elleder V, Spittler A, Stift J, Pop L, Gruenberger B, Gruenberger T, Brostjan C
JournalOncoimmunology
PubMed ID27471631
We have previously reported that intermediate monocytes (CD14(++)/CD16(+)) were increased in colorectal cancer (CRC) patients, while the subset of pro-angiogenic TIE2-expressing monocytes (TEMs) was not significantly elevated. This study was designed to evaluate changes in frequency and function of intermediate monocytes and TEMs during chemotherapy and anti-angiogenic cancer treatment and ... More
Pharmacologically active microcarriers delivering BDNF within a hydrogel: Novel strategy for human bone marrow-derived stem cells neural/neuronal differentiation guidance and therapeutic secretome enhancement.
AuthorsKandalam S, Sindji L, Delcroix GJ, Violet F, Garric X, André EM, Schiller PC, Venier-Julienne MC, des Rieux A, Guicheux J, Montero-Menei CN
JournalActa Biomater
PubMed ID27865962
Stem cells combined with biodegradable injectable scaffolds releasing growth factors hold great promises in regenerative medicine, particularly in the treatment of neurological disorders. We here integrated human marrow-isolated adult multilineage-inducible (MIAMI) stem cells and pharmacologically active microcarriers (PAMs) into an injectable non-toxic silanized-hydroxypropyl methylcellulose (Si-HPMC) hydrogel. The goal is to ... More
CD40 signaling instructs chronic lymphocytic leukemia cells to attract monocytes via the CCR2 axis.
Authorsvan Attekum MHA, van Bruggen JAC, Slinger E, Lebre MC, Reinen E, Kersting S, Eldering E, Kater AP
JournalHaematologica
PubMed ID28971904
Chronic lymphocytic leukemia (CLL) cells are provided with essential survival and proliferative signals in the lymph node microenvironment. Here, CLL cells engage in various interactions with bystander cells such as T cells and macrophages. Phenotypically distinct types of tumor infiltrating macrophages can either be tumor supportive (M2) or play a ... More
Quantitative analysis of serum chemokines associated with treatment failure of direct-acting antivirals in chronic hepatitis C.
AuthorsUmemura T, Yamazaki T, Joshita S, Sugiura A, Fujimori N, Matsumoto A, Ota M, Tanaka E
JournalCytokine
PubMed ID30296712
Although serum chemokine levels have been reported to influence the outcome of interferon-based treatment in patients with chronic hepatitis C, their effect on the hepatitis C virus (HCV) response to direct-acting antiviral agents (DAAs), which can achieve high rates of a sustained virological response (SVR), is largely unknown. To clarify ... More
Host chemokine signature as a biomarker for the detection of pre-cancerous cervical lesions.
AuthorsBhatia R, Kavanagh K, Stewart J, Moncur S, Serrano I, Cong D, Cubie HA, Haas JG, Busby-Earle C, Williams ARW, Howie SEM, Cuschieri K
JournalOncotarget
PubMed ID29719625
The ability to distinguish which hrHPV infections predispose to significant disease is ever more pressing as a result of the increasing move to hrHPV testing for primary cervical screening. A risk-stratifier or "triage" of infection should ideally be objective and suitable for automation given the scale of screening. ... More
Schistosoma mansoni PCR
AuthorsArndts K, Elfaki TEM, Jelden N, Ritter M, Wiszniewsky A, Katawa G, Goreish IA, Atti El Mekki MEYA, Doenhoff MJ, Hoerauf A, Layland LE
JournalClin Exp Immunol
PubMed ID30724349
Infections with Schistosoma mansoni remain a major health problem in the Sudan where endemic communities, such as those in Kassala and Khartoum states, continue to face severe social-economic difficulties. Our previous immunoepidemiological findings revealed different immune [cytokine and S. mansoni egg (SEA) antibody] profiles in individuals with active infections (eggs ... More