Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning.
AuthorsLai WS, Xu B, Westphal KG, Paterlini M, Olivier B, Pavlidis P, Karayiorgou M, Gogos JA
JournalProc Natl Acad Sci U S A
PubMed ID17077150
'There is accumulating evidence that AKT signaling plays a role in the pathogenesis of schizophrenia. We asked whether Akt1 deficiency in mice results in structural and functional abnormalities in prefrontal cortex (PFC). Exploratory transcriptional profiling revealed concerted alterations in the expression of PFC genes controlling synaptic function, neuronal development, myelination, ... More
Inhibitor of apoptosis protein (IAP) profiling in experimental autoimmune encephalomyelitis (EAE) implicates increased XIAP in T lymphocytes.
AuthorsMoore CS, Hebb AL, Robertson GS,
JournalJ Neuroimmunol
PubMed ID18055022
'In multiple sclerosis (MS) and its widely accepted animal model, experimental autoimmune encephalomyelitis (EAE), the failure of autoreactive immune cells to undergo apoptosis is thought to contribute to CNS tissue damage and disease progression. Promoting apoptosis of myelin-reactive immune cells in diseases such as MS, may delay disease progression and ... More
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis.
'The misfolding of the prion protein (PrP(c)) is a central event in prion diseases, yet the normal function of PrP(c) remains unknown. PrP(c) has putative roles in many cellular processes including signaling, survival, adhesion, and differentiation. Given the abundance of PrP(c) in the developing and mature mammalian CNS, we investigated ... More
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.
AuthorsAoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA
JournalNat Neurosci
PubMed ID16311588
Uptake of the neurotransmitter glutamate is effected primarily by transporters expressed on astrocytes, and downregulation of these transporters leads to seizures and neuronal death. Neurons also express a glutamate transporter, termed excitatory amino acid carrier-1 (EAAC1), but the physiological function of this transporter remains uncertain. Here we report that genetically ... More
Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination.
AuthorsKanaan A, Farahani R, Douglas RM, Lamanna JC, Haddad GG
JournalAm J Physiol Regul Integr Comp Physiol
PubMed ID16322350
Chronic hypoxia, whether continuous (CCH) or intermittent (CIH), occurs in many neonatal pathological conditions, such as bronchopulmonary dysplasia and obstructive sleep apnea. In this study, we explored the effect of CCH and CIH on cerebral capillary density and myelination. We subjected CD-1 mice starting at postnatal day 2 to either ... More
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination.
Authors
JournalJ Exp Med
PubMed ID34424266
Targeting senescent cells improves functional recovery after spinal cord injury.
Authors
JournalCell Rep
PubMed ID34233184
TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice.
Authors
JournalNat Commun
PubMed ID34099715
Stroke induces disease-specific myeloid cells in the brain parenchyma and pia.
Authors
JournalNat Commun
PubMed ID35177618
Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis.
Authors
JournalBrain
PubMed ID30657878
Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis.
Authors
JournalJ Exp Med
PubMed ID32078678
Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery.
Authors
JournalCell Rep
PubMed ID34706241
Placental endocrine function shapes cerebellar development and social behavior.
Authors
JournalNat Neurosci
PubMed ID34400844
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Authors
JournalCell Rep
PubMed ID35196494
Disruption of Sema3A/Plexin-A1 inhibitory signalling in oligodendrocytes as a therapeutic strategy to promote remyelination.