Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain.
AuthorsKim DH, Lilliehook C, Roides B, Chen Z, Chang M, Mobashery S, Goldman SA,
JournalJ Neurosci
PubMed ID18171938
Testosterone-induced neuronal addition to the adult songbird vocal control center, HVC, requires the androgenic induction of vascular endothelial growth factor (VEGF), followed by VEGF-stimulated angiogenesis. The expanded vasculature acts as a source of BDNF, which supports the immigration of new neurons from the overlying ventricular zone. In tumorigenesis, a similar ... More
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