Thermo Scientific Chemicals

2,2-Difluoroacetophenone, 95%, Thermo Scientific Chemicals

Catalog number: H25750.MD
250 mg, Each
Thermo Scientific Chemicals

2,2-Difluoroacetophenone, 95%, Thermo Scientific Chemicals

Catalog number: H25750.MD
250 mg, Each
Quantity
Catalog number: H25750.MD
also known as H25750-MD
Price (JPY)

Chemical Identifiers

CAS
395-01-7
IUPAC Name
2,2-difluoro-1-phenylethan-1-one
Molecular Formula
C8H6F2O
InChI Key
OLYKCPDTXVZOQF-UHFFFAOYSA-N
SMILES
FC(F)C(=O)C1=CC=CC=C1
Refractive Index
1.4950-1.5010 @ 20°C
Identification (FTIR)
Conforms
Appearance (Color)
Clear colorless to pale yellow or pale pink
Assay (GC)
≥94.0%
Form
Liquid

Description

2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.

Solubility
Immiscible with water.

Notes
Incompatible with strong oxidizing agents and strong acids.
RUO – Research Use Only

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