4-Amino-1-Boc-piperidine, 97%
4-Amino-1-Boc-piperidine, 97%
4-Amino-1-Boc-piperidine, 97%
Thermo Scientific Chemicals

4-Amino-1-Boc-piperidine, 97%

CAS: 87120-72-7 | C10H21N2O2 | 201.29 g/mol
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1 g
5 g
Catalog number H30779.03
also known as H30779-03
Price (EUR)
59,50
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Quantity:
1 g
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Price (EUR)
59,50
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Chemical Identifiers
CAS87120-72-7
IUPAC Name1-[(tert-butoxy)carbonyl]piperidin-4-aminium
Molecular FormulaC10H21N2O2
InChI KeyLZRDHSFPLUWYAX-UHFFFAOYSA-O
SMILESCC(C)(C)OC(=O)N1CCC([NH3+])CC1
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to pale yellow to cream
FormCrystals or powder or crystalline powder or chunks
Assay (GC)≥96.0%
4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.

Solubility
Insoluble in water.

Notes
Air Sensitive, store away from air. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
RUO – Research Use Only

General References:

  1. Calum Macleod; Blanca I Martinez-Teipel; William M Barker; Roland E Dolle. Annulation of primary amines to piperazines and diazaspirocycles utilizing alpha-methyl benzyl resin. Journal of Combinatorial Chemistry,2006, 8(1), 132-140.
  2. Demont, E. et al. Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors. J. Med. Chem,2015, 58 (14), 5649-5673.