4,6-Dichloropyrimidine-5-carboxaldehyde is used as a substrate in the synthesis of N-terminal surrogate in amino acid and peptide analogues.
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Aplicaciones
El 4,6-dicloropirimidina-5-carboxaldehído se utiliza como sustrato en la síntesis del sustituto de N-terminal en análogos de aminoácidos y péptidos.
Notas
Incompatible con agentes oxidantes fuertes y ácidos fuertes. Almacenar en un lugar fresco.
RUO – Research Use Only
General References:
- Li, B.; Yue, Z.; Xiang, H.; Lv, L.; Song, S.; Miao, Z.; Yang, C. Catalyst-free synthesis of benzofuran-fused pyrido[4,3-d]pyrimidines from 2-(2-hydroxyaryl)acetonitrile and 4,6-dichloropyrimidine-5-carbaldehyde through domino condensation reactions. RCS Adv. 2015, 4 (1), 358-364.
- Schenone, S.; Radi, M.; Musumeci, F.; Brullo, C.; Botta, M. Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies. Chem. Rev. 2014, 114 (14), 7189-7238.