Cryopreserved human hepatocytes for use in transporter-mediated uptake applications.
Cells per vial: 4-8 million
Prototypical hepatic uptake transporter substrates taurocholate and estradiol-17β-glucuronide have been assessed to qualify the transport function of hepatic NTCP (SLC10A1) and OATP1B14/3 (SLCO1B1/3), respectively. The transport of each substrate (radiolabeled) was monitored by scintillation analysis and active transport values (37°C - 4°C) determined by linear regression.
Get the Results You Need with GIBCO® Hepatocytes High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities • Proper morphology • Viabilities generally >75% • Attachment efficiency • Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.