Human Plateable Hepatocytes, Uptake Qualified

Catalog number: HMCPUS

Gibco™  Related applications: Hepatocytes & Hepatic Models | Pharma & Biopharma | Primary Cell Culture | Target-Based ADME⁄Tox Assays

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Description

Cryopreserved human hepatocytes for use in transporter-mediated uptake applications.

Cells per vial: 4-8 million

Prototypical hepatic uptake transporter substrates taurocholate and estradiol-17β-glucuronide have been assessed to qualify the transport function of hepatic NTCP (SLC10A1) and OATP1B14/3 (SLCO1B1/3), respectively. The transport of each substrate (radiolabeled) was monitored by scintillation analysis and active transport values (37°C - 4°C) determined by linear regression.

Get the Results You Need with GIBCO® Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.

Each lot is tested for:

• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity

For research use only. Not intended for human or animal therapeutic or diagnostic use.

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Learn more about our cryopreserved hepatocytes

Learn about our full line of hepatocytes
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Cell Passage Number: Passage 0
Cell Type: Hepatocytes
Culture Type: Adherent Cell Culture
Donor Source: Single Donor
Form: Cryopreserved
Format: Tube(s)
Number of Cells: 4-8 x 106
Product Size: 1.5 mL
Species: Human

Contents & storage

Vials of cryopreserved hepatocytes should be stored in a cryostorage dewar or -135°C freezer.

Documents

Manuals & protocols