Gibco™

Human Plateable Hepatocytes, Uptake Qualified

Catalog number:  HMCPUS

Related applications:

Industrial & Applied Science

| Cell Culture

Back to top

Description

Cryopreserved human hepatocytes for use in transporter-mediated uptake applications.

Cells per vial: 4-8 million

Prototypical hepatic uptake transporter substrates taurocholate and estradiol-17β-glucuronide have been assessed to qualify the transport function of hepatic NTCP (SLC10A1) and OATP1B14/3 (SLCO1B1/3), respectively. The transport of each substrate (radiolabeled) was monitored by scintillation analysis and active transport values (37°C - 4°C) determined by linear regression.

Get the Results You Need with GIBCO® Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.

Each lot is tested for:

• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity

For research use only. Not intended for human or animal therapeutic or diagnostic use.

Related Link

Learn more about our cryopreserved hepatocytes

Learn about our full line of hepatocytes
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Cell Passage Number: Passage 0
Culture Type: Adherent Cell Culture
Form: Cryopreserved
No. of Cells: 4-8 x 106
Product Line: Gibco®
Donor Source: Single Donor
Species: Human
Cell Type: Hepatocytes
Format: Tube(s)

Contents & storage

Vials of cryopreserved hepatocytes should be stored in a cryostorage dewar or -135°C freezer.