In vitro studies with renal proximal tubule cells show direct cytotoxicity of Androctonus australis hector scorpion venom triggered by oxidative stress, caspase activation and apoptosis.
AuthorsSaidani C, Hammoudi-Triki D, Laraba-Djebari F, Taub M,
JournalToxicon
PubMed ID27470530
'Scorpion envenomation injures a number of organs, including the kidney. Mechanisms proposed to explain the renal tubule injury include direct effects of venom on tubule epithelial cells, as well as indirect effects of the autonomic nervous system, and inflammation. Here, we report direct effects of Androctonus australis hector (Aah) scorpion ... More
A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy.
Authors
JournalElife
PubMed ID25564732
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages.
Authors
JournalCell Host Microbe
PubMed ID28867389
Morphokinetic-related response to stress in individually cultured bovine embryos.
AuthorsSilva T, Santos EC, Annes K, Soares CA, Leite RF, Lima CB, Milazzotto MP
JournalTheriogenology
PubMed ID27298151
The kinetics of in vitro-produced (IVP) bovine embryos is related to embryo viability, metabolism, and epigenetic patterns. Therefore, we believe that embryos with different speeds of development also respond differently to stress. In the present study, we performed global metabolic analysis (matrix-assisted laser desorption ionization time of flight mass spectrometry [MALDI-TOF]) ... More
The role of RhoA in retrograde neuronal death and axon regeneration after spinal cord injury.
AuthorsHu J, Zhang G, Rodemer W, Jin LQ, Shifman M, Selzer ME
JournalNeurobiol Dis
PubMed ID27888137
Paralysis following spinal cord injury (SCI) is due to interruption of axons and their failure to regenerate. It has been suggested that the small GTPase RhoA may be an intracellular signaling convergence point for several types of growth-inhibiting extracellular molecules. Even if this is true in vitro, it is not ... More
PTPs Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury.
AuthorsRodemer W, Zhang G, Sinitsa I, Hu J, Jin LQ, Li S, Selzer ME
JournalFront Cell Neurosci
PubMed ID32265663
Traumatic spinal cord injury (SCI) results in persistent functional deficits due to the lack of axon regeneration within the mammalian CNS. After SCI, chondroitin sulfate proteoglycans (CSPGs) inhibit axon regrowth ... More