Thermo Scientific™

UltiMate™ 3000 Closed Sampler XRS System

 Related applications:
Industrial Chromatography
Collect high resolution data with the shortest run times in a flexible, high throughput system. The Thermo Scientific™ UltiMate™ 3000 Closed Sampler XRS system lets you achieve lower detection limits and combine multiple detectors to produce more high quality data in less time. Its quaternary UHPLC solvent delivery module delivers faster gradient responses than many binary systems. In addition, the system backpressure capabilities support very long, sub-2µm particle size columns for ultra-high resolution experiments in very complex or uncharacterized samples.

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Recommended Use

The UltiMate 3000 Closed Sampler XRS system is recommended for laboratories supporting life science, drug discovery, drug development, personal care products, food and nutraceuticals research, as well as demanding applications in the chemical industry. In combination with Thermo Scientific mass spectrometers or charged aerosol detectors, the Closed Sampler XRS system shows exceptional capabilities for all 1mm to 4.6mm internal column diameter-based LC workflows.

It is an excellent choice for comparative studies like metabolomics, authenticity and toxicity screening, discovery of new therapeutically active substances, forensics, in depth nutritional studies and food safety investigations.

Ensuring Excellent Chromatography

  • Up to 2mL/min flow rate supporting up to 125 MPa (18250 psi/1250 bar) backpressure for fast and highly resolving column technologies
  • A quaternary gradient UHPLC pump offers gradient delay volumes as little as 200µL for fast gradient response
  • Ultra-low carryover, large sample capacity (split loop, up to 3 well plates or sample racks) Closed Sampler minimizes contamination between samples to deliver more accurate results
  • Dispersion-free UV-monitoring provides additional sample information without compromising chromatographic resolution
  • Get near-zero dead volume for optimal peak shapes even over extended periods using Thermo Scientific™ Dionex™ Viper™ Fingertight fitting system
  • Precise and accurate flow rates for stable retention times, robust peak integration, and confident identification from advanced flow technology
  • Optimize mixing efficiency with adjustable gradient delay volumes using Thermo Scientific™ Dionex™ SpinFlow™ technology
Chromeleon CDS Software Makes Operation Easy
  • Integrated service and validation monitoring with Thermo Scientific™ Dionex™ Chromeleon™ CDS, versions 6.x and 7.x
  • Automated system startup, standby and shutdown with Chromeleon CDS software, versions 6.x and 7.x
  • Compatible with Chromeleon 7.x eWorkflow walk-up solution and advanced reporting features

Choose the Right Configuration for You

  • Four-solvent channel quaternary pump for versatile gradient methods (LPG-3400XRS)
  • Thermostatted Closed Autosampler (WPS-3000TXRS)
  • Thermostatted column compartment with up to two field upgradeable column switching valves (TCC-3000RS)
  • Diode array, multiple wavelength, variable wavelength, fluorescence, charged aerosol, refractive index, or mass spectrometry detectors
  • [Bullet 5] New near-zero peak dispersion UV monitor flow cell (45nL cell volume, for VWD-3x00 series)
  • [Bullet 6] Chromeleon 7.2 CDS software packages (standalone, networked, remote data processing and/or control)


Manuals & protocols