Thermo Scientific™

Exactive™ Plus EMR Orbitrap™ LC-MS System

 Related applications:
Industrial Mass Spectrometry

While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-resolution accurate-mass Thermo Scientific™ Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.

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Confidently Identify, Characterize, and Quantify Intact Proteins

  • Extended m/z 350–20,000 mass range enables analysis of larger proteins, antibodies, antibody-drug conjugates, glycoforms, and protein assemblies
  • Improved transmission of higher-mass ions provides stronger signals
  • Resolving power up to 140,000 FWHM enables separation of isoforms and determination of glycosylation states
  • Excellent mass accuracy ensures confident identification
  • Access to short transients improves signal-to-noise ratios
  • Compatibility with Thermo Scientific Protein Deconvolution software designed specifically for identification and characterization of intact proteins


  • Modified HCD cell controls make it easier to optimize experimental conditions
  • Intuitive operating software reduces learning curves

For Research Use Only. Not for use in diagnostic procedures.


Access to our expert service team, information on support plans, parts and consumables resources, and other instrument services.  USA only [EN]


Improved analysis of protein-ligand interactions

Discover how the extended mass range and high-resolution, accurate-mass capabilities of the Exactive Plus EMR hybrid quadrupole-Orbitrap mass spectrometer improve analysis of native (intact) proteins, facilitating analysis of protein-ligand interactions and similar applications.

View the webinar 


Manuals & protocols