Thermo Scientific™

LC IsoLink™ IRMS System

Related applications:

Industrial Mass Spectrometry

Open new frontiers in isotope ratio mass spectrometry (IRMS) with the Thermo Scientific™ LC IsoLink™ IRMS System. By coupling HPLC and IRMS, the LC IsoLink IRMS System facilitates sensitive, accurate online determination of 13C/12C ratios for compounds that are either too volatile or thermally labile to be separated by gas chromatography. The system's interface preserves chromatographic resolution integrity and enables acquisition of isotopic data on an HPLC time scale. This system is ideal for applications including metabolism studies, food and pharmaceutical authentication, doping control, and biogeochemistry research.

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  • Chromatographic resolution is preserved and isotope ratio data are acquired on an HPLC time scale
  • Accuracy and precision compare favorably with elemental analyzer IRMS but 100 times less sample is required
  • Sensitivity is sufficient for isotope ratio determination of 13C/12C on sample amounts as low as 50 ng in direct injection mode
  • The interface has very few variables (e.g., He flow), simplifying method development and instrument operation
  • Complete system control by Thermo Scientific™ Isodat™ software allows automated data acquisition, analysis, and report generation for high sample throughput
  • Samples are oxidized in solution and extracted before analysis. Because the liquid phase is not vaporized, inorganic buffers do not accumulate in the system, enabling it to be nearly maintenance-free

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