The HR Multi-Attribute Method (HR MAM) is a powerful high resolution accurate mass (HRAM) mass spectrometry (MS)-based workflow, delivering comprehensive characterization and monitoring of biotherapeutic products. Built within a safe compliant environment, the HR MAM allows characterization of biologics with ease and allows product quality attributes to be monitored throughout every stage of the drug development process, while also enabling purity testing and new peak detection. The high quality data generated by the combination of high resolution chromatography and HRAM MS is seamlessly interrogated by a powerful software workstream to provide the maximum confidence in securing product quality.
The HR Multi-Attribute Method (HR MAM) includes all the necessary components for a successful biopharmaceutical quality attribute characterization and quantitation workflow, including the following:
Key benefits of HR MAM:
Know more unknowns
Take advantage of another dimension and find out what is missed. Detect sample impurities with HRAM-based new peak detection.
Seamlessly transfer your analytical method into routine monitoring.
Apply generated protein characterization data to quality attribute identification using BioPharma Finder software. Integrate seamlessly into routine and compliant monitoring using the powerful MS processing features of Chromeleon Chromatography Data System (CDS).