Thermo Scientific™

Orbitrap Exploris™ Isotope Solutions

Catalog number: IQLAAMGAATFARBMBNP
Thermo Scientific™

Orbitrap Exploris™ Isotope Solutions

Catalog number: IQLAAMGAATFARBMBNP
Open new dimensions in isotope ratio analysis with Thermo Scientific™ Orbitrap Exploris™ Isotope Solutions. Preserve intramolecular isotopic information throughout the analysis and determine previously inaccessible isotopologues by the combination of soft electrospray ionization (ESI) and high-resolution accurate mass (HRAM) sensitivity. The powerful workflow comprises a dedicated sample introduction concept based on Dual Inlet principles, a distinctive method setup, and a data evaluation framework to determine isotope ratio data from the ratios of intact isotopologues of molecular ions.
 
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IQLAAMGAATFARBMBNP
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DescriptionOrbitrap Exploris Isotope Solutions
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DescriptionOrbitrap Exploris Isotope Solutions
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Technology
Orbitrap Exploris Isotope Solutions dedicated workflow includes:

  • Thermo Scientific™ Orbitrap Exploris™ 120/240/480 MS
  • Data evaluation Package for Isotope Ratio MS
  • Dual syringe inlet
  • Optional Thermo Scientific™ Vanquish™ Neo UHPLC System for additional automation

Sample introduction

  • Dual Syringe Inlet system utilizing the diverter valve option of the Orbitrap Exploris MS
  • In-flow Injection automated approach based on the Vanquish Neo UHPLC System

Analytical capabilities

  • Isotope ratios at natural abundance: direct measurements of individual analytes in liquid samples and simultaneous acquisition of all major and some minor isotopologues, enabling abundance determination of 13C, 15N, 18O, 17O, 2H, 34S, 33S, 36S, and more
  • Position-specific isotope ratios: controlled fragmentation of organic molecular species that enables unique position-specific isotope analysis
  • Clumped isotopes analysis: measurements of isotopologues with multiple rare isotope substitutions

Applications

  • Biogeochemical cycles research using multiple isotopologues of CNSOH bearing species (e.g., nitrate, sulfate, phosphate, acetate, and other simple organics)
  • Study of geological proxies and their formation (e.g., formation of alkenones and fatty acids)
  • Deconvoluting complex metabolic pathways by tracing metabolite transformations
  • Food authenticity using isotope ratios of multiple elements and position-specific isotope analysis