Naloxone hydrochloride, 98%

Name: Naloxone hydrochloride, 98%
SKU: J60013.03

Naloxone hydrochloride, CAS # 357-08-4, is involved in the blockade of the mu-opioid receptor and removal of other compounds from the receptor site. | CAS: 357-08-4 | C19H22ClNO4 | 363.838 g/mol

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Catalog number J60013.03

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1 g

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Chemical Identifiers

CAS357-08-4

IUPAC Namehydrogen (1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7,9,11(18)-trien-14-one chloride

Molecular FormulaC19H22ClNO4

InChI KeyRGPDIGOSVORSAK-STHHAXOLSA-N

SMILES[H+].[Cl-].OC1=CC=C2C[C@H]3N(CC=C)CC[C@@]45[C@@H](OC1=C24)C(=O)CC[C@@]35O

Specifications

Specification Sheet

Appearance (Color)White to off-white

FormCrystals or powder or crystalline powder

Assay from Suppliers CofA≥97.5%

Assay from Suppliers CofAChloride, Cl: 9.54-9.94%

Loss on Drying≤11.0%

A specific opiate antagonist. Blocks the action of sigma-agonists at opioid sites.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Naloxone hydrochloride the hydrochloride salt of the anti-opioid naloxone

Application

Naloxone is a fast-acting inverse agonist of the mu-opioid receptor that can be used to competitively inhibit the binding of opioid compounds

RUO – Research Use Only

General References:

Meng F, Li Y, Sun H, Li C, Li Q, Law PY, Loh HH, Liang L, Zheng H. Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner. Cell Mol Neurobiol. 2021 Jul;41(5):1031-1038. doi: 10.1007/s10571-020-00970-8. Epub 2020 Sep 28. PMID: 32989585.
Chen J, Liang L, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, Pei D, Sun H, Zheng H. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. FASEB J. 2020 Apr;34(4):5917-5930. doi: 10.1096/fj.201902873R. Epub 2020 Mar 10. PMID: 32154623.