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Thermo Scientific Chemicals
Oxonic acid potassium salt
Inhibitor of uricase | CAS: 2207-75-2 | C4H2KN3O4 | 195.18 g/mol
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Chemical Identifiers
CAS2207-75-2
IUPAC Namepotassium 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylate
Molecular FormulaC4H2KN3O4
InChI KeyIAPCTXZQXAVYNG-UHFFFAOYSA-M
SMILES[K+].[O-]C(=O)C1=NC(=O)NC(=O)N1
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Specifications
Specification Sheet
Specification SheetFormPowder
Appearance (Color)White to off-white
Assay from Supplier's CofA≥97.0%
Infrared spectrumConforms
Oxonic acid potassium salt is an inhibitor of uricase. This product has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Oxonic acid potassium salt is an inhibitor of uricase. This product has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
Solubility
Soluble in hot water.
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents.
Oxonic acid potassium salt is an inhibitor of uricase. This product has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
Solubility
Soluble in hot water.
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- T Shirasaka; Y Shimamoto; M Fukushima. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Research.1993, 53 (17), 4004-4009.
- Yasushi Habu; Ikuko Yano; Masahiro Okuda; Atsushi Fukatsu; Ken-ichi Inui. Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney. Biochemical Pharmacology. 2005, 69 (6), 993-999.