Thermo Scientific™

G418 disulfate, Cell Culture Reagent, Thermo Scientific™

25g, Each
Thermo Scientific™

G418 disulfate, Cell Culture Reagent, Thermo Scientific™

25g, Each
Quantity
Informational:Informational:This chemical may require us to obtain additional information for our regulatory and chemical compliance records. If required, we will contact you for this information once your order is placed.
Catalog number: J62671.14
also known as J62671-14
Price (USD)
Price: 1,039.00 / Each
Your Price:
Quantity
-

Chemical Identifiers

CAS
108321-42-2
IUPAC Name
5-amino-6-[(4,6-diamino-3-{[3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl)oxy]-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
Molecular Formula
C20H44N4O18S2
InChI Key
UHEPSJJJMTWUCP-UHFFFAOYNA-N
SMILES
OS(O)(=O)=O.OS(O)(=O)=O.CNC1C(O)C(OC2C(N)CC(N)C(OC3OC(C(C)O)C(O)C(O)C3N)C2O)OCC1(C)O
pH
4.6 to 6.0
Assay (special)
Biological assay (ED50 resistant): ? 2500 µg/ ml
Assay (special)
Biological assay (ED50 sensitive): ? 400 µg/ ml
Potency
? 720 units/ mg
Solution Test
Solubility in 100 mg/ml: Clear to slightly hazy solution

Description

G418 disulfate is an aminoglycoside that is toxic to bacteria, yeast, protozoans and helminths. It prevents protein synthesis by blocking the elongation step in prokaryotic and eukaryotic ribosomes. It is used as a selection agent for G418 resistant bacteria or fungi after transformation.

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General description
• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is a bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis
Applications
• G418 sulfate can be used for selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory grade for applications such as biochemistry

RUO – Research Use Only