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G418 disulfate, Cell Culture Reagent, Thermo Scientific Chemicals
Catalog number: J62671.14
25 g, Each
Thermo Scientific Chemicals
G418 disulfate, Cell Culture Reagent, Thermo Scientific Chemicals
Catalog number: J62671.14
25 g, Each
Quantity
Catalog number: J62671.14
also known as J62671-14
Price (EUR)
1.734,61 Online price
1.949,00
Each
Quantity
-
Chemical Identifiers
CAS
108321-42-2
IUPAC Name
(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
Molecular Formula
C20H44N4O18S2
InChI Key
UHEPSJJJMTWUCP-KETIWVBHNA-N
SMILES
OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O
Specifications
Specification SheetAssay (special)
Biological assay (ED50 resistant): ? 2500 µg/ ml
Assay (special)
Biological assay (ED50 sensitive): ? 400 µg/ ml
Potency
? 720 units/ mg
Solution Test
Solubility in 100 mg/ml: Clear to slightly hazy solution
Appearance (Color)
White
Description
G418 disulfate is an aminoglycoside that is toxic to bacteria, yeast, protozoans and helminths. It prevents protein synthesis by blocking the elongation step in prokaryotic and eukaryotic ribosomes. It is used as a selection agent for G418 resistant bacteria or fungi after transformation.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is a bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis
Applications
• G418 sulfate can be used for selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory grade for applications such as biochemistry
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Respiratory Sensitization
Category 1
Skin Sensitization
Category 1
Label Elements
Signal Word
Danger
Hazard Statements
H317 - May cause an allergic skin reaction
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements
P280 - Wear protective gloves/protective clothing
P285 - In case of inadequate ventilation wear respiratory protection
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P333 + P313 - If skin irritation or rash occurs: Get medical advice/attention
P342 + P311 - If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician