The Tango™ EDG2-bla U2OS cells contain the human Endothelial Differentiation Gene 2 (EDG2) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin/TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.
The Tango™ EDG2-bla U2OS cells are functionally validated for Z' and EC50 concentrations of LPA (18: 1). In addition, Tango™ EDG2-bla U2OS cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
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