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Smad cell signaling is a critical pathway involved in cell growth and proliferation. The CellSensor® SBE-bla HEK 293T cell line is responsive to transforming growth factor-beta 1 (TGF-ß1) and can be used to probe the Smad signaling pathway.The CellSensor® SBE-bla HEK 293T cell line contains the !-lactamase reporter gene under the control of the Smad Binding Element (SBE). The SBE-bla construct was transduced into HEK 293T cells by lentivirus to obtain the cell line. Flow cytometry was used to isolate a clone responsive to TGF-ß1 a dose response curve for this cell line using TGF-B1 is available in the validation packet data. Academic and non-profit customers, please inquire for special pricing.
For Research Use Only. Not for use in diagnostic procedures.
Cell-based beta lactamase reporter gene
TGF beta/BMP pathway, TGF beta R
Contents & storage
CellSensor® Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.