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CHO-K1 cells contain the human Dopamine Receptor 2 (D2) stably integrated into the GeneBLAzer™ Gqo5-NFAT-bla
CHO-K1 cell line. GeneBLAzer™ Gqo5-NFAT-bla
CHO-K1 cells (K1536
) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Chimeric G protein, Gqo5.
The GeneBLAzer™ D2-Gqo5-NFAT-bla
CHO-K1 cells are functionally validated for Z' and EC50
concentrations of apomorphine. In addition, GeneBLAzer™ D2-Gqo5-NFAT-bla
CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The D2 receptor is found primarily in the brain. There are two forms of D2 which are created by alternate splicing: a short form and a long form. This assay uses the long form, although little difference in ligand binding or signaling has been seen between the two forms.
For Research Use Only. Not for use in diagnostic procedures.