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      GeneBLAzer® 5TH1A-Gα15-NFAT-bla CHO-K1 Cells

      Catalog number: K1712

       Related applications: Pharma & Biopharma | Target & Lead Identification & Validation

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      Description

      GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells contain the human 5-HT Receptor 1A (5HT1A) stably integrated into the GeneBLAzer® Gα15-NFAT-bla CHO-K1 cell line. GeneBLAzer® Gα15-NFAT-bla CHO-K1 cells (Cat. no. K1537) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Promiscuous G protein, Gα15.

      The GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of 5-CT. In addition, GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

      Agonists and antagonists of the 5HT receptors are in various stages of clinical trials for the treatment of neurological disorders like anxiety, insomnia, and depression.

      For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
      For Research Use Only. Not for use in diagnostic procedures.

      Specifications

      Gene Symbol: 5HT1A
      Accession Number: NM_000524
      Cell Line: CHO-K1
      Cell State: Dividing Cells
      Detection Method: Fluorescent
      Druggable Target: GPCRs
      Population Status: Single Cell Clone Origin
      Product Line: GeneBLAzer®
      Product Size: 2 x 106 cells
      Reporter: BLA (Beta-Lactamase)
      System: GeneBLAzer™
      Technique: FRET

      Contents & storage

      Contents:
      K1712 GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells
      (LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
      Includes:
      • GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 cells
      • GeneBLAzer® 5HT1A Gα15-NFAT-bla CHO-K1 Assay Protocol
      • Certificate of Analysis

      Storage:
      The GeneBLAzer® 5HT1A Gα15 CHO-K1 DA cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.

      Documents

      Manuals & protocols