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GeneBLAzer™ AVPR1a-NFAT-bla CHO-K1 Cells
Catalog number: K1715
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Description
GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells contain the human Arginine Vasopressin Receptor 1a (AVPR1a) stably integrated into the CellSensor® NFAT-bla CHO-K1 cell line. CellSensor® NFAT-bla CHO-K1 cells (Cat. no. K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.The GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of Vasopressin. In addition, GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The family of receptors that recognize vasopressin and oxytocin consists of four members: vasopressin receptors 1a (AVPR1a), 1b (AVPR1b), and 2 (AVPR2), and the oxytocin (OT) receptor. AVPR1a, AVPR1b, and the OT receptor couple to the Gq/G11 class of G proteins and trigger the release of intracellular calcium when stimulated. AVPR2 receptors couple to Gs proteins and activate adenyl cyclase. All three AVPR receptors have high affinity for their endogenous ligand, vasopressin, but AVPR1b has less affinity for oxytocin than does AVPR1a or AVPR2. The hormones vasopressin and oxytocin are synthesized in the hypothalamus. Oxytocin causes contractions in the uterus during childbirth. The main functions of arginine vasopressin (AVP) are reabsorption of water by the kidneys and contraction of smooth muscle in arteries. This system may also play a role in memory and learning.
For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
| Gene Symbol: | AVPR1a |
|---|---|
| Accession Number: | NM_000706.3 |
| Cell Line: | CHO-K1 |
| Cell State: | Dividing Cells |
| Detection Method: | Fluorescent |
| Druggable Target: | GPCRs |
| Population Status: | Single Cell Clone Origin |
| Product Line: | GeneBLAzer® |
| Product Size: | 2 x 106 cells |
| Reporter: | BLA (Beta-Lactamase) |
| System: | GeneBLAzer™ |
| Technique: | FRET |
Contents & storage
Contents:
K1715 GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells
• GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 Assay Protocol
• Certificate of Analysis
Storage:
The GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
K1715 GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells
• GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 Assay Protocol
• Certificate of Analysis
Storage:
The GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
