GeneBLAzer™ AVPR2 CRE-bla CHO-K1 cells contain the human Arginine Vasopressin 2 (AVPR2) receptor stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.
The GeneBLAzer™ AVPR2 CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of dDAVP. In addition, GeneBLAzer™ AVPR2 CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
Agonists and antagonists of the AVPR2 receptors are in various stages of clinical trials for the treatment of hypertension and as diuretics.
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For Research Use Only. Not for use in diagnostic procedures.