During checkout, this product may be reported as "Out of Stock" with an Estimated Availability date. The Actual Availability date for this product may be earlier. Send inquiries regarding Actual Availability date, including the catalog number, to discoverysciences@lifetech.com.

GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 Cells

Catalog number:  K1721

 Related applications:

Pharma & Biopharma

| Target & Lead Identification & Validation

Error loading your content!

  Catalog number
Select a plan
Unit size
Price ({{currency}}) Availability Qty
{{product.sku}} {{product.sku}} also known as {{product.formattedSku}} 
Pro add-ons

Your on-site stock

›› {{supplyCenter.scName}}({{scProduct.stockOnHand}} In stock)
›› {{supplyCenter.scName}}(Out of stock)
›› {{supplyCenter.scName}}
This item is not currently available on-site. Depending on your Supply Center settings you may be able to add the item to cart above else use the Order Non-Stocked Items' tab on the Supply Center home page.
Back to top


GeneBLAzer® CysLT2-NFAT-bla CHO-K1 cells contain the human Cysteinyl receptor (CysLT2) stably integrated into the CellSensor® NFAT-bla CHO-K1 cell line. CellSensor® NFAT-bla CHO-K1 cells (Cat. no. K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.

The GeneBLAzer® CysLT2-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of LTD4. In addition, GeneBLAzer® CysLT2-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

Cysteinyl leukotrienes play a role in the patho-physiology of numerous inflammatory disorders, including chronic asthmatic inflammation. The cysteine leukotriene receptors, CysLT1 and CysLT2, are thus primary targets for anti-asthma drugs. A number of cysteinyl leukotrienes (including LTC4, LTD4, and LTE4) have been identified, and are known to function as inflammatory mediators as well as being potent smooth muscle contractile agents.

Leukotriene receptor antagonists (LTRAs) reduce the effect of allergic inflammation and athsma by blocking cysteine leukotriene activity. Several CysLT antagonists, such as montelukast, zafirlucast, and pranlukast, are currently used in the treatment of asthma.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
For Research Use Only. Not for use in diagnostic procedures.


Gene Symbol: CysLT2
Accession Number: NM_020377.2
Cell Line: CHO-K1
Cell State: Dividing Cells
Detection Method: Fluorescent
Druggable Target: GPCRs
Population Status: Single Cell Clone Origin
Product Line: GeneBLAzer®
Product Size: 2 x 106 cells
Reporter: BLA (Beta-Lactamase)
System: GeneBLAzer™
Technique: FRET

Contents & storage

K1721 GeneBLAzer® CysLT2-NFAT-bla CHO-K1 cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
• GeneBLAzer® CysLT2-NFAT-bla CHO-K1 cells
• GeneBLAzer® CysLT2-NFAT-bla CHO-K1 Assay Protocol
• Certificate of Analysis

The GeneBLAzer® CysLT2-NFAT-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.


Manuals & protocols