Thermo Scientific™

GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 Cells

Catalog number: K1721
Thermo Scientific™

GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 Cells

Catalog number: K1721
Catalog Number
K1721
Unit Size
2 × 10^6 cells
Price (USD)
Price: 9,190.00
Your Price:
Availability
-
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
K17212 × 10^6 cells
Price: 9,190.00
Your Price:
-
Product Overview
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GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells contain the human Cysteinyl receptor (CysLT2) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line. CellSensor™ NFAT-bla CHO-K1 cells (Cat. no. K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.

The GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of LTD4. In addition, GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

Cysteinyl leukotrienes play a role in the patho-physiology of numerous inflammatory disorders, including chronic asthmatic inflammation. The cysteine leukotriene receptors, CysLT1 and CysLT2, are thus primary targets for anti-asthma drugs. A number of cysteinyl leukotrienes (including LTC4, LTD4, and LTE4) have been identified, and are known to function as inflammatory mediators as well as being potent smooth muscle contractile agents.

Leukotriene receptor antagonists (LTRAs) reduce the effect of allergic inflammation and athsma by blocking cysteine leukotriene activity. Several CysLT antagonists, such as montelukast, zafirlucast, and pranlukast, are currently used in the treatment of asthma.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number
NM_020377.2
Assay Entry
Cell-based beta lactamase reporter gene
Cell State
Dividing Cells
Detection Method
Fluorescent
For Use With (Application)
FRET
Gene Symbol
CysLT2
Population Status
Single Cell Clone Origin
Product Line
GeneBLAzer™
Reporter Gene
BLA (Beta-Lactamase)
Target Entry
CysLT2
Cell Line
CHO-K1
System Type
GeneBLAzer™
Druggable Target
GPCRs

Contents & Storage

Contents:
K1721 GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells
• GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 Assay Protocol
• Certificate of Analysis

Storage:
The GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.