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Thermo Scientific™

GeneBLAzer™ MC1R-CRE-bla CHO-K1 Cells

Catalog number: K1724
Thermo Scientific™

GeneBLAzer™ MC1R-CRE-bla CHO-K1 Cells

Catalog number: K1724
Catalog Number
K1724
Unit Size
2 x 106 cells
Price (USD)
8,140.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
K17242 x 106 cells
8,140.00
Your Price:
***
Product Overview
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GeneBLAzer® MC1R CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 1 (MC1R) stably integrated into the CellSensor® CRE-bla CHO-K1 cell line. CellSensor® CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.

The GeneBLAzer® MC1R CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of NDP-α-MSH. In addition, GeneBLAzer® MC1R CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The MC1 receptor (previously refered to as MSH-R) is the melanocyte-stimulating hormone receptor expressed in melanocytes and involved in the regulation of pigment production. Two types of melanin exist: pheomelanin and eumelanin. Loss in function mutations in MC1R are associated with increased pheomelanin production, leading to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. MC1R is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles for MC1R have been identified correlating to skin and hair color, providing evidence that MC1R is an important component in determining normal human pigment variation. Additionally, the involvement of the melanocortins in inflammation and exocrine secretion are likely to spur the development of selective MC1 and MC5 compounds

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Specifications

Accession Number
NM_002386.2
Assay Entry
Cell-based beta lactamase reporter gene
Cell State
Dividing Cells
Detection Method
Fluorescent
For Use With (Application)
FRET
Gene Symbol
MC1R
Population Status
Single Cell Clone Origin
Product Line
GeneBLAzer™
Reporter Gene
BLA (Beta-Lactamase)
Target Entry
MC1R
Cell Line
CHO-K1
System Type
GeneBLAzer™
Druggable Target
GPCRs

Contents & Storage

Contents:
K1724 GeneBLAzer™ MC1R CRE-bla CHO-K1 cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• GeneBLAzer™ MC1R CRE-bla CHO-K1 cells
• GeneBLAzer™ MC1R CRE-bla CHO-K1 Assay Protocol
• Certificate of Analysis

Storage:
The GeneBLAzer™ MC1R CRE-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.

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